Seroatlas · Human Serome Atlas

ODF2L

Protein BCAP

Also known as: KIAA1229, ODF2L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9ULJ1
Gene: ODF2L
Ensembl: ENSG00000122417
Chromosome: 1
Canonical length: 636 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Involved in negative regulation of cilium assembly. Located in centriolar satellite and ciliary basal body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

636 residues, UniProt reviewed canonical sequence.

>Q9ULJ1|ODF2L
     1  MEKAVNDGSH SEELFCHLKT ISEKEDLPRC TSESHLSCLK QDILNEKTEL EATLKEAELV
    61  THSVELLLPL FKDTIEKINF ENANLSALNL KISEQKEILI KELDTFKSVK LALEHLLRKR
   121  DYKQTGDNLS SMLLENLTDN ESENTNLKKK VFEKEAHIQE LSCLFQSEKA NTLKANRFSQ
   181  SVKVVHERLQ IQIHKREAEN DKLKEYVKSL ETKIAKWNLQ SRMNKNEAIV MKEASRQKTV
   241  ALKKASKVYK QRLDHFTGAI EKLTSQIRDQ EAKLSETISA SNAWKSHYEK IVIEKTELEV
   301  QIETMKKQII NLLEDLKKME DHGKNSCEEI LRKVHSIEYE NETLNLENTK LKLRFPCRIT
   361  ESKNMNILIV LDMLCYISSE KTTLAALKDE VVSVENELSE LQEVEKKQKT LIEMYKTQVQ
   421  KLQEAAEIVK SRCENLLHKN NQITKTKNKN VEKMRGQMES HLKELERVCD SLTAAERRLH
   481  ECQESLQCCK GKCADQEHTI RELQGQVDGN HNLLTKLSLE EENCLIQLKC ENLQQKLEQM
   541  DAENKELEKK LANQEECLKH SNLKFKEKSA EYTALARQLE AALEEGRQKV AEEIEKMSSR
   601  ESALQIKILD LETELRKKNE EQNQLVCKMN SDPETP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ODF2L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

retina: 25 nTPM
spleen: 19 nTPM
pituitary gland: 15 nTPM
lung: 15 nTPM
breast: 14 nTPM
thyroid gland: 14 nTPM

Single-cell type

respiratory ciliated cells: 594 nCPM
endometrial ciliated cells: 561 nCPM
ependymal cells: 446 nCPM
prostatic club cells: 371 nCPM
epididymal efferent duct ciliated cells: 325 nCPM
fallopian tube ciliated cells: 322 nCPM

Immune cell

MAIT T-cell: 31 nTPM
T-reg: 20 nTPM
memory CD4 T-cell: 19 nTPM
gdT-cell: 15 nTPM
memory B-cell: 11 nTPM
naive B-cell: 11 nTPM

Brain region

cerebral cortex: 59 nTPM
cerebellum: 53 nTPM
white matter: 51 nTPM
choroid plexus: 48 nTPM
medulla oblongata: 47 nTPM
midbrain: 45 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.22
gnomAD pLI: 0
gnomAD missense Z: -0.2
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Outer dense fiber protein 2/Protein BCAP

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ODF2L as an antibody target. Whether an autoantibody or antibody against ODF2L could matter depends on whether native ODF2L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ODF2L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ODF2L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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