Seroatlas · Human Serome Atlas

ODAPH

Odontogenesis associated phosphoprotein

Also known as: AI2A4, C4orf26, FLJ23657, ODAPH_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q17RF5
Gene
ODAPH
Ensembl
ENSG00000174792
Chromosome
4
Canonical length
130 aa
Protein class
Disease related genes, Human disease related genes, Predicted secreted proteins
Secretome location
Secreted in other tissues

OverviewNCBI Gene

Dental enamel forms the outer cap of teeth and is the hardest substance found in vertebrates. This gene is thought to encode an extracellular matrix acidic phosphoprotein that has a function in enamel mineralization during amelogenesis. Mutations in this gene are associated with recessive hypomineralized amelogenesis imperfecta. [provided by RefSeq, Oct 2012]

Canonical amino-acid sequenceUniProt

130 residues, UniProt reviewed canonical sequence.

>Q17RF5|ODAPH
     1  MARRHCFSYW LLVCWLVVTV AEGQEEVFTP PGDSQNNADA TDCQIFTLTP PPAPRSPVTR
    61  AQPITKTPRC PFHFFPRRPR IHFRFPNRPF VPSRCNHRFP FQPFYWPHRY LTYRYFPRRR
   121  LQRGSSSEES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ODAPH can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.69
Highest tissue expression
5.5 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 5.5 nTPM
  • spinal cord: 1.1 nTPM
  • midbrain: 1 nTPM
  • skeletal muscle: 0.8 nTPM
  • hippocampal formation: 0.7 nTPM
  • amygdala: 0.6 nTPM

Single-cell type

  • syncytiotrophoblasts: 35 nCPM
  • extravillous trophoblasts: 14 nCPM
  • plasma cells: 9.3 nCPM
  • migrating cytotrophoblasts: 7.2 nCPM
  • late primary spermatocytes: 4.1 nCPM
  • early spermatids: 3.2 nCPM

Immune cell

  • basophil: 11 nTPM
  • MAIT T-cell: 0.3 nTPM
  • naive B-cell: 0.3 nTPM
  • neutrophil: 0.2 nTPM
  • classical monocyte: 0.1 nTPM
  • intermediate monocyte: 0.1 nTPM

Brain region

  • white matter: 3.4 nTPM
  • cerebral cortex: 2.5 nTPM
  • pons: 2.4 nTPM
  • cerebellum: 2.2 nTPM
  • medulla oblongata: 2.1 nTPM
  • midbrain: 2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ODAPH.

Disease | AllUniProt

Conditions ODAPH is implicated in, by any mechanism.

  • Amelogenesis imperfecta, hypomaturation type, 2A4 (AI2A4) MIM:614832

Disease | GeneticClinVar

7 pathogenic / likely-pathogenic of 24 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Amelogenesis imperfecta hypomaturation type 2A4
  • ODAPH-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.67
gnomAD pLI
0.05
DepMap mean gene effect
0.11
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Odontogenesis associated phosphoprotein
  • Odontogenesis associated phosphoprotein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ODAPH as an antibody target. Whether an autoantibody or antibody against ODAPH could matter depends on whether native ODAPH is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ODAPH is annotated as secreted, so native ODAPH circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ODAPH as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ODAPH. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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