Seroatlas · Human Serome Atlas

OCM

Oncomodulin-1

Also known as: OCM1, ONCO_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0CE72
Gene: OCM
Ensembl: ENSG00000122543
Chromosome: 7
Canonical length: 109 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Oncomodulin is a high-affinity calcium ion-binding protein. It belongs to the superfamily of calmodulin proteins, also known as the EF-hand proteins. Oncomodulin is an oncodevelopmental protein found in early embryonic cells in the placenta and also in tumors. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

109 residues, UniProt reviewed canonical sequence.

>P0CE72|OCM
     1  MSITDVLSAD DIAAALQECR DPDTFEPQKF FQTSGLSKMS ANQVKDVFRF IDNDQSGYLD
    61  EEELKFFLQK FESGARELTE SETKSLMAAA DNDGDGKIGA EEFQEMVHS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OCM can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 6.7 nTPM

Expression across tissuesHPA

Tissue

amygdala: 6.7 nTPM
cerebellum: 2.1 nTPM
lymph node: 2.1 nTPM
testis: 2 nTPM
hippocampal formation: 1.5 nTPM
hypothalamus: 1.5 nTPM

Single-cell type

retinal horizontal cells: 4 nCPM
late spermatids: 3.6 nCPM
kupffer cells: 3.1 nCPM
early spermatids: 2.8 nCPM
late primary spermatocytes: 2.6 nCPM
medullary thymic epithelial cells: 2.4 nCPM

Immune cell

T-reg: 2.7 nTPM
naive CD4 T-cell: 1.6 nTPM
naive B-cell: 1.4 nTPM
memory CD4 T-cell: 1.1 nTPM
eosinophil: 0.8 nTPM
neutrophil: 0.6 nTPM

Brain region

amygdala: 3 nTPM
hypothalamus: 2 nTPM
cerebellum: 1.7 nTPM
cerebral cortex: 1.6 nTPM
basal ganglia: 1.5 nTPM
white matter: 1.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.94
gnomAD pLI: 0
gnomAD missense Z: -0.61
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

calcium ion binding

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OCM as an antibody target. Whether an autoantibody or antibody against OCM could matter depends on whether native OCM is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OCM is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label OCM as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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