OCC1
Overexpressed in colon carcinoma 1 protein
Also known as: AGD3, C12orf75, OCC-1, OCC1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8TAD7
- Gene
- OCC1
- Ensembl
- ENSG00000235162
- Chromosome
- 12
- Canonical length
- 63 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Vesicles
OverviewNCBI Gene
No narrative summary is available for OCC1 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
63 residues, UniProt reviewed canonical sequence.
>Q8TAD7|OCC1
1 MGCGNSTATS AGAGQGPAGA AKDVTEESVT EDDKRRNYGG VYVGLPSEAV NMVSSQTKTV
61 RKNLocalizationUniProt · AlphaFold · HPA
Whether an antibody against OCC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.64
- Highest tissue expression
- 129 nTPM
Expression across tissuesHPA
Tissue
- blood vessel: 129 nTPM
- seminal vesicle: 103 nTPM
- kidney: 60 nTPM
- stomach: 47 nTPM
- prostate: 39 nTPM
- gallbladder: 36 nTPM
Single-cell type
- extravillous trophoblasts: 1,968 nCPM
- megakaryocytes: 1,224 nCPM
- epididymal clear cells: 1,102 nCPM
- pdcs: 984 nCPM
- parietal cells: 716 nCPM
- endometrial ciliated cells: 693 nCPM
Immune cell
- plasmacytoid DC: 665 nTPM
- memory CD8 T-cell: 170 nTPM
- gdT-cell: 166 nTPM
- T-reg: 145 nTPM
- naive CD8 T-cell: 103 nTPM
- total PBMC: 89 nTPM
Brain region
- cerebellum: 18 nTPM
- hypothalamus: 17 nTPM
- cerebral cortex: 16 nTPM
- spinal cord: 12 nTPM
- midbrain: 9.7 nTPM
- medulla oblongata: 9.3 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.9
- gnomAD pLI
- 0.64
- DepMap mean gene effect
- -0.12
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- Overexpressed in colon carcinoma 1
- OCC1 family
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads OCC1 as an antibody target. Whether an autoantibody or antibody against OCC1 could matter depends on whether native OCC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
OCC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label OCC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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