Seroatlas · Human Serome Atlas

OC90

Otoconin-90

Also known as: OC90_HUMAN, PLA2L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q02509
Gene
OC90
Ensembl
ENSG00000253117
Chromosome
8
Canonical length
477 aa
Protein class
Predicted secreted proteins
Secretome location
Secreted in other tissues

OverviewNCBI Gene

Predicted to enable calcium ion binding activity; calcium-dependent phospholipase A2 activity; and phospholipid binding activity. Predicted to be involved in otolith mineralization; phosphatidylcholine metabolic process; and phosphatidylglycerol metabolic process. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

477 residues, UniProt reviewed canonical sequence.

>Q02509|OC90
     1  MIAFLLTSVL MIPHAGGHPL DTPHLPQELP PGLPNNINIT FFSGMFKNVE SVAEIFDCLG
    61  PHFTWLQAVF TNFPVLIQFV NGMKCVAGLC PRDFEDYGCT CRFEMEGLPV DESDSCCFQH
   121  RRCYEEAAEM DCLQDPAKLS TEVNCVSKKI ICESKDNCEH LLCTCDKAAI ECLARSSLNS
   181  SLNLLDTSFC LAQTPETTIK EDLTTLLPRV VPVEPTDTSL TALSGEEAGH DQEGVGAARA
   241  TSPPGSAEIV ATRVTAKIVT LVPAGIKSLG LAVSSVENDP EETTEKACDR FTFLHLGSGD
   301  NMQVMPQLGE MLFCLTSRCP EEFESYGCYC GQEGRGEPRD DLDRCCLSHH CCLEQVRRLG
   361  CLLERLPWSP VVCVDHTPKC GGQSLCEKLL CACDQTAAEC MTSASFNQSL KSPSRLGCPG
   421  QPAACEDSLH PVPAAPTLGS SSEEDSEEDP PQEDLGRAKR FLRKSLGPLG IGPLHGR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OC90 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
0.3 nTPM

Expression across tissuesHPA

Tissue

  • midbrain: 0.3 nTPM
  • cerebral cortex: 0.1 nTPM
  • choroid plexus: 0.1 nTPM
  • hypothalamus: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM

Single-cell type

  • other brain neurons: 0.9 nCPM
  • brain inhibitory neurons: 0.4 nCPM
  • brain excitatory neurons: 0.2 nCPM
  • oligodendrocyte progenitor cells: 0.1 nCPM
  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • midbrain: 0.4 nTPM
  • thalamus: 0.3 nTPM
  • cerebral cortex: 0.2 nTPM
  • hypothalamus: 0.2 nTPM
  • hippocampal formation: 0.1 nTPM
  • pons: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.27
gnomAD pLI
0
gnomAD missense Z
-1.01
DepMap mean gene effect
0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of OC90 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OC90 as an antibody target. Whether an autoantibody or antibody against OC90 could matter depends on whether native OC90 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OC90 is annotated as secreted, so native OC90 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label OC90 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/OC90. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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