Seroatlas · Human Serome Atlas

OBP2B

Odorant-binding protein 2b

Also known as: hOBPIIb, LCN14, OBP2B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NPH6
Gene: OBP2B
Ensembl: ENSG00000171102
Chromosome: 9
Canonical length: 170 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted in other tissues

OverviewNCBI Gene

Predicted to enable odorant binding activity. Predicted to be involved in chemosensory behavior and sensory perception of smell. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

170 residues, UniProt reviewed canonical sequence.

>Q9NPH6|OBP2B
     1  MKTLFLGVTL GLAAALSFTL EEEDITGTWY VKAMVVDKDF PEDRRPRKVS PVKVTALGGG
    61  KLEATFTFMR EDRCIQKKIL MRKTEEPGKY SAYGGRKLMY LQELPRRDHY IFYCKDQHHG
   121  GLLHMGKLVG RNSDTNREAL EEFKKLVQRK GLSEEDIFTP LQTGSCVPEH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OBP2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 9.4 nTPM

Expression across tissuesHPA

Tissue

testis: 9.4 nTPM
skin: 2.4 nTPM
breast: 1.6 nTPM
fallopian tube: 0.9 nTPM
endometrium: 0.5 nTPM
ovary: 0.1 nTPM

Single-cell type

breast secretory cells: 14 nCPM
sertoli cells: 13 nCPM
fallopian secretory cells: 7.1 nCPM
granulosa cells: 6.5 nCPM
epididymal principal cells: 5.3 nCPM
breast hormone-responsive cells: 4.6 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.55
gnomAD pLI: 0
gnomAD missense Z: 0.25

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OBP2B as an antibody target. Whether an autoantibody or antibody against OBP2B could matter depends on whether native OBP2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OBP2B is annotated as secreted, so native OBP2B circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label OBP2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...