Seroatlas · Human Serome Atlas

OBP2A

Odorant-binding protein 2a

Also known as: hOBPIIa, LCN13, OBP, OBP2A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NY56
Gene: OBP2A
Ensembl: ENSG00000122136
Chromosome: 9
Canonical length: 170 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted in other tissues

OverviewNCBI Gene

This gene encodes a small extracellular protein belonging to the lipocalin superfamily. The protein is thought to transport small, hydrophobic, volatile molecules or odorants through the nasal mucus to olfactory receptors, and may also function as a scavenger of highly concentrated or toxic odors. The protein is expressed as a monomer in the nasal mucus, and can bind diverse types of odorants with a higher affinity for aldehydes and fatty acids. This gene and a highly similar family member are located in a cluster of lipocalin genes on chromosome 9. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

170 residues, UniProt reviewed canonical sequence.

>Q9NY56|OBP2A
     1  MKTLFLGVTL GLAAALSFTL EEEDITGTWY VKAMVVDKDF PEDRRPRKVS PVKVTALGGG
    61  NLEATFTFMR EDRCIQKKIL MRKTEEPGKF SAYGGRKLIY LQELPGTDDY VFYCKDQRRG
   121  GLRYMGKLVG RNPNTNLEAL EEFKKLVQHK GLSEEDIFMP LQTGSCVLEH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OBP2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 23 nTPM
testis: 5.7 nTPM
skin: 2 nTPM
breast: 1.5 nTPM
pituitary gland: 0.6 nTPM
placenta: 0.6 nTPM

Single-cell type

fallopian secretory cells: 52 nCPM
sertoli cells: 4.3 nCPM
breast hormone-responsive cells: 3.3 nCPM
late spermatids: 1.9 nCPM
endometrial glandular cells: 1.6 nCPM
plasma cells: 1.5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 0.1 nTPM
cerebral cortex: 0.1 nTPM
pons: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
choroid plexus: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.66
gnomAD pLI: 0
gnomAD missense Z: -0.03
DepMap mean gene effect: 0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OBP2A as an antibody target. Whether an autoantibody or antibody against OBP2A could matter depends on whether native OBP2A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OBP2A is annotated as secreted, so native OBP2A circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label OBP2A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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