Seroatlas · Human Serome Atlas

OARD1

ADP-ribose glycohydrolase OARD1

Also known as: C6orf130, dJ34B21.3, MGC19570, OARD1_HUMAN, TARG1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y530
Gene: OARD1
Ensembl: ENSG00000124596
Chromosome: 6
Canonical length: 152 aa
Protein class: Disease related genes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

The protein encoded by this gene is a deacylase that can convert O-acetyl-ADP-ribose to ADP-ribose and acetate, O-propionyl-ADP-ribose to ADP-ribose and propionate, and O-butyryl-ADP-ribose to ADP-ribose and butyrate. The ADP-ribose product is able to inhibit these reactions through a competitive feedback loop. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

152 residues, UniProt reviewed canonical sequence.

>Q9Y530|OARD1
     1  MASSLNEDPE GSRITYVKGD LFACPKTDSL AHCISEDCRM GAGIAVLFKK KFGGVQELLN
    61  QQKKSGEVAV LKRDGRYIYY LITKKRASHK PTYENLQKSL EAMKSHCLKN GVTDLSMPRI
   121  GCGLDRLQWE NVSAMIEEVF EATDIKITVY TL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OARD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 56 nTPM

Expression across tissuesHPA

Tissue

testis: 56 nTPM
liver: 55 nTPM
kidney: 42 nTPM
retina: 41 nTPM
pancreas: 38 nTPM
stomach: 37 nTPM

Single-cell type

cardiomyocytes: 497 nCPM
late spermatids: 287 nCPM
late primary spermatocytes: 242 nCPM
early spermatids: 207 nCPM
parietal cells: 196 nCPM
myonuclei: 175 nCPM

Immune cell

basophil: 49 nTPM
memory B-cell: 46 nTPM
NK-cell: 45 nTPM
naive B-cell: 44 nTPM
eosinophil: 43 nTPM
naive CD4 T-cell: 37 nTPM

Brain region

white matter: 40 nTPM
medulla oblongata: 30 nTPM
basal ganglia: 30 nTPM
pons: 28 nTPM
spinal cord: 28 nTPM
cerebellum: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.34
gnomAD pLI: 0
gnomAD missense Z: 0.32
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ADP-ribosylglutamate hydrolase activity
O-acetyl-ADP-ribose deacetylase activity
purine nucleoside binding
ADP-ribosyl-[dinitrogen reductase] hydrolase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Macro domain
Macro domain-like
Macro domain
ADP-ribose derivative metabolism enzymes

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OARD1 as an antibody target. Whether an autoantibody or antibody against OARD1 could matter depends on whether native OARD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OARD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label OARD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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