OAF
Out at first protein homolog
Also known as: MGC52117, OAF_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q86UD1
- Gene
- OAF
- Ensembl
- ENSG00000184232
- Chromosome
- 11
- Canonical length
- 273 aa
- Protein class
- Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
- Subcellular location
- Nucleoplasm
- Secretome location
- Secreted - unknown location
OverviewNCBI Gene
No narrative summary is available for OAF in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
273 residues, UniProt reviewed canonical sequence.
>Q86UD1|OAF
1 MRLPGVPLAR PALLLLLPLL APLLGTGAPA ELRVRVRLPD GQVTEESLQA DSDADSISLE
61 LRKPDGTLVS FTADFKKDVK VFRALILGEL EKGQSQFQAL CFVTQLQHNE IIPSEAMAKL
121 RQKNPRAVRQ AEEVRGLEHL HMDVAVNFSQ GALLSPHLHN VCAEAVDAIY TRQEDVRFWL
181 EQGVDSSVFE ALPKASEQAE LPRCRQVGDH GKPCVCRYGL SLAWYPCMLK YCHSRDRPTP
241 YKCGIRSCQK SYSFDFYVPQ RQLCLWDEDP YPGLocalizationUniProt · AlphaFold · HPA
Whether an antibody against OAF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.33
- Highest tissue expression
- 408 nTPM
Expression across tissuesHPA
Tissue
- liver: 408 nTPM
- adrenal gland: 92 nTPM
- pancreas: 76 nTPM
- basal ganglia: 69 nTPM
- cervix: 68 nTPM
- adipose tissue: 66 nTPM
Single-cell type
- pancreatic acinar cells: 431 nCPM
- müller glia: 377 nCPM
- hepatocytes: 282 nCPM
- adrenal cortex cells: 161 nCPM
- lymphatic endothelial cells: 155 nCPM
- colonocytes: 139 nCPM
Immune cell
- classical monocyte: 3.3 nTPM
- myeloid DC: 2.4 nTPM
- intermediate monocyte: 1.6 nTPM
- total PBMC: 0.8 nTPM
- plasmacytoid DC: 0.5 nTPM
- non-classical monocyte: 0.3 nTPM
Brain region
- basal ganglia: 52 nTPM
- cerebral cortex: 38 nTPM
- amygdala: 33 nTPM
- hippocampal formation: 32 nTPM
- thalamus: 27 nTPM
- white matter: 27 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.18
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.74
- DepMap mean gene effect
- 0.08
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- Out at first protein
- Out at first protein, BRICHOS-like domain
- Out at first, C-terminal
- Out at first
- Out at first, C-terminal
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads OAF as an antibody target. Whether an autoantibody or antibody against OAF could matter depends on whether native OAF is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
OAF is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label OAF as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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