Seroatlas · Human Serome Atlas

NXPH4

Neurexophilin-4

Also known as: NPH4, NXPH4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95158
Gene: NXPH4
Ensembl: ENSG00000182379
Chromosome: 12
Canonical length: 308 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted in brain

OverviewNCBI Gene

Predicted to enable signaling receptor binding activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to be located in extracellular region. Predicted to be active in GABA-ergic synapse. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

308 residues, UniProt reviewed canonical sequence.

>O95158|NXPH4
     1  MRLLPEWFLL LFGPWLLRKA VSAQIPESGR PQYLGLRPAA AGAGAPGQQL PEPRSSDGLG
    61  VGRAWSWAWP TNHTGALARA GAAGALPAQR TKRKPSIKAA RAKKIFGWGD FYFRVHTLKF
   121  SLLVTGKIVD HVNGTFSVYF RHNSSSLGNL SVSIVPPSKR VEFGGVWLPG PVPHPLQSTL
   181  ALEGVLPGLG PPLGMAAAAA GPGLGGSLGG ALAGPLGGAL GVPGAKESRA FNCHVEYEKT
   241  NRARKHRPCL YDPSQVCFTE HTQSQAAWLC AKPFKVICIF VSFLSFDYKL VQKVCPDYNF
   301  QSEHPYFG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NXPH4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 19 nTPM
skin: 18 nTPM
cerebral cortex: 4.7 nTPM
retina: 4.7 nTPM
prostate: 4.1 nTPM
salivary gland: 3.9 nTPM

Single-cell type

cytotrophoblasts: 39 nCPM
syncytiotrophoblasts: 35 nCPM
müller glia: 18 nCPM
oocytes: 14 nCPM
prostatic glandular cells: 13 nCPM
basal keratinocytes: 12 nCPM

Immune cell

memory B-cell: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

pons: 39 nTPM
hypothalamus: 28 nTPM
medulla oblongata: 28 nTPM
cerebellum: 16 nTPM
cerebral cortex: 16 nTPM
spinal cord: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.87
gnomAD pLI: 0.23
gnomAD missense Z: 1.46
DepMap mean gene effect: 0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

signaling receptor binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NXPH4 as an antibody target. Whether an autoantibody or antibody against NXPH4 could matter depends on whether native NXPH4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NXPH4 is annotated as secreted, so native NXPH4 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label NXPH4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...