Seroatlas · Human Serome Atlas

NXPH3

Neurexophilin-3

Also known as: NPH3, NXPH3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95157
Gene: NXPH3
Ensembl: ENSG00000182575
Chromosome: 17
Canonical length: 252 aa
Protein class: Predicted secreted proteins
Subcellular location: Vesicles,Mitotic spindle
Secretome location: Secreted in brain

OverviewNCBI Gene

Predicted to enable signaling receptor binding activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

252 residues, UniProt reviewed canonical sequence.

>O95157|NXPH3
     1  MQLTRCCFVF LVQGSLYLVI CGQDDGPPGS EDPERDDHEG QPRPRVPRKR GHISPKSRPM
    61  ANSTLLGLLA PPGEAWGILG QPPNRPNHSP PPSAKVKKIF GWGDFYSNIK TVALNLLVTG
   121  KIVDHGNGTF SVHFQHNATG QGNISISLVP PSKAVEFHQE QQIFIEAKAS KIFNCRMEWE
   181  KVERGRRTSL CTHDPAKICS RDHAQSSATW SCSQPFKVVC VYIAFYSTDY RLVQKVCPDY
   241  NYHSDTPYYP SG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NXPH3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 35 nTPM
cerebellum: 22 nTPM
endometrium: 8.4 nTPM
cerebral cortex: 8.3 nTPM
colon: 7.2 nTPM
cervix: 6.9 nTPM

Single-cell type

smooth muscle cells: 30 nCPM
peritubular myoid cells: 17 nCPM
vascular smooth muscle cells: 17 nCPM
retinal bipolar cells: 15 nCPM
pituicytes/fscs: 7.4 nCPM
brain excitatory neurons: 6.6 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 41 nTPM
pons: 20 nTPM
thalamus: 14 nTPM
cerebral cortex: 13 nTPM
medulla oblongata: 13 nTPM
midbrain: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.79
gnomAD pLI: 0.28
gnomAD missense Z: 0.56
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NXPH3 as an antibody target. Whether an autoantibody or antibody against NXPH3 could matter depends on whether native NXPH3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NXPH3 is annotated as secreted, so native NXPH3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label NXPH3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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