Seroatlas · Human Serome Atlas

NXPH2

Neurexophilin-2

Also known as: NPH2, NXPH2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95156
Gene: NXPH2
Ensembl: ENSG00000144227
Chromosome: 2
Canonical length: 264 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted in brain

OverviewNCBI Gene

Predicted to enable signaling receptor binding activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

264 residues, UniProt reviewed canonical sequence.

>O95156|NXPH2
     1  MRLRPLPLVV VPGLLQLLFC DSKEVVHATE GLDWEDKDAP GTLVGNVVHS RIISPLRLFV
    61  KQSPVPKPGP MAYADSMENF WDWLANITEI QEPLARTKRR PIVKTGKFKK MFGWGDFHSN
   121  IKTVKLNLLI TGKIVDHGNG TFSVYFRHNS TGLGNVSVSL VPPSKVVEFE VSPQSTLETK
   181  ESKSFNCRIE YEKTDRAKKT ALCNFDPSKI CYQEQTQSHV SWLCSKPFKV ICIYIAFYSV
   241  DYKLVQKVCP DYNYHSETPY LSSG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NXPH2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 4.1 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 4.1 nTPM
ovary: 4.1 nTPM
kidney: 3.8 nTPM
amygdala: 2.3 nTPM
retina: 2.1 nTPM
hippocampal formation: 1.5 nTPM

Single-cell type

renal collecting duct intercalated cells: 316 nCPM
brain inhibitory neurons: 81 nCPM
respiratory ionocytes: 76 nCPM
salivary ionocytes: 49 nCPM
retinal bipolar cells: 36 nCPM
podocytes: 28 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 28 nTPM
midbrain: 16 nTPM
medulla oblongata: 16 nTPM
spinal cord: 4.5 nTPM
cerebral cortex: 4.3 nTPM
basal ganglia: 4.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.36
gnomAD pLI: 0.93
gnomAD missense Z: 1.5
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NXPH2 as an antibody target. Whether an autoantibody or antibody against NXPH2 could matter depends on whether native NXPH2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NXPH2 is annotated as secreted, so native NXPH2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label NXPH2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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