Seroatlas · Human Serome Atlas

NXPH1

Neurexophilin-1

Also known as: NXPH1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P58417
Gene: NXPH1
Ensembl: ENSG00000122584
Chromosome: 7
Canonical length: 271 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted in brain

OverviewNCBI Gene

This gene is a member of the neurexophilin family and encodes a secreted protein with a variable N-terminal domain, a highly conserved, N-glycosylated central domain, a short linker region, and a cysteine-rich C-terminal domain. This protein forms a very tight complex with alpha neurexins, a group of proteins that promote adhesion between dendrites and axons. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

271 residues, UniProt reviewed canonical sequence.

>P58417|NXPH1
     1  MQAACWYVLF LLQPTVYLVT CANLTNGGKS ELLKSGSSKS TLKHIWTESS KDLSISRLLS
    61  QTFRGKENDT DLDLRYDTPE PYSEQDLWDW LRNSTDLQEP RPRAKRRPIV KTGKFKKMFG
   121  WGDFHSNIKT VKLNLLITGK IVDHGNGTFS VYFRHNSTGQ GNVSVSLVPP TKIVEFDLAQ
   181  QTVIDAKDSK SFNCRIEYEK VDKATKNTLC NYDPSKTCYQ EQTQSHVSWL CSKPFKVICI
   241  YISFYSTDYK LVQKVCPDYN YHSDTPYFPS G

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NXPH1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 40 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 40 nTPM
cerebral cortex: 27 nTPM
hypothalamus: 21 nTPM
amygdala: 15 nTPM
basal ganglia: 11 nTPM
hippocampal formation: 11 nTPM

Single-cell type

oligodendrocyte progenitor cells: 1,899 nCPM
brain inhibitory neurons: 681 nCPM
adrenal cortex cells: 641 nCPM
adrenal medulla cells: 415 nCPM
thyrotrophs: 372 nCPM
lactotrophs: 247 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 57 nTPM
thalamus: 53 nTPM
hypothalamus: 30 nTPM
medulla oblongata: 29 nTPM
pons: 26 nTPM
basal ganglia: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.62
gnomAD pLI: 0.48
gnomAD missense Z: 0.27
DepMap mean gene effect: 0.15
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

modulation of chemical synaptic transmission

Molecular functions

signaling receptor binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NXPH1 as an antibody target. Whether an autoantibody or antibody against NXPH1 could matter depends on whether native NXPH1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NXPH1 is annotated as secreted, so native NXPH1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label NXPH1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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