NUPR2
Nuclear protein 2
Also known as: NUPR1L, NUPR2_HUMAN, P8
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A6NF83
- Gene
- NUPR2
- Ensembl
- ENSG00000185290
- Chromosome
- 7
- Canonical length
- 97 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
Involved in several processes, including cellular response to starvation; negative regulation of cell population proliferation; and negative regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
97 residues, UniProt reviewed canonical sequence.
>A6NF83|NUPR2
1 MEAPAERALP RLQALARPPP PISYEEELYD CLDYYYLRDF PACGAGRSKG RTRREQALRT
61 NWPAPGGHER KVAQKLLNGQ RKRRQRQLHP KMRTRLTLocalizationUniProt · AlphaFold · HPA
Whether an antibody against NUPR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.5
- Highest tissue expression
- 332 nTPM
Expression across tissuesHPA
Tissue
- testis: 332 nTPM
- kidney: 18 nTPM
- thyroid gland: 15 nTPM
- pituitary gland: 12 nTPM
- salivary gland: 7.3 nTPM
- amygdala: 6.8 nTPM
Single-cell type
- late spermatids: 27,700 nCPM
- early spermatids: 4,255 nCPM
- late primary spermatocytes: 1,322 nCPM
- epididymal clear cells: 147 nCPM
- parietal cells: 108 nCPM
- gastric chief cells: 58 nCPM
Immune cell
- naive CD4 T-cell: 5.2 nTPM
- basophil: 2 nTPM
- memory CD4 T-cell: 1.8 nTPM
- naive CD8 T-cell: 1.4 nTPM
- plasmacytoid DC: 0.8 nTPM
- total PBMC: 0.8 nTPM
Brain region
- hypothalamus: 9.3 nTPM
- cerebellum: 8.4 nTPM
- cerebral cortex: 6.8 nTPM
- basal ganglia: 6.5 nTPM
- pons: 5.9 nTPM
- midbrain: 5.2 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.94
- gnomAD pLI
- 0
- DepMap mean gene effect
- -0.19
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- cellular response to starvation
- DNA damage response
- negative regulation of cell cycle
- negative regulation of cell population proliferation
- negative regulation of transcription by RNA polymerase II
- regulation of cell cycle
- regulation of transcription by RNA polymerase II
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads NUPR2 as an antibody target. Whether an autoantibody or antibody against NUPR2 could matter depends on whether native NUPR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
NUPR2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label NUPR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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