Seroatlas · Human Serome Atlas

NUP62CL

Nucleoporin-62 C-terminal-like protein

Also known as: FLJ20130, N62CL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H1M0
Gene: NUP62CL
Ensembl: ENSG00000198088
Chromosome: X
Canonical length: 184 aa
Protein class: Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a protein containing a domain found in nucleoporins which are glycoproteins found in nuclear pore complexes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

184 residues, UniProt reviewed canonical sequence.

>Q9H1M0|NUP62CL
     1  MQFTSISNSL TSTAAIGLSF TTSTTTTATF TTNTTTTITS GFTVNQNQLL SRGFENLVPY
    61  TSTVSVVATP VMTYGHLEGL INEWNLELED QEKYFLLQAT QVNAWDHTLI ENGEMIRILH
   121  GEVNKVKLDQ KRLEQELDFI LSQQQELEFL LTYLEESTRD QSGLHYLQDA DEEHVEISTR
   181  SAEF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUP62CL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

epididymis: 16 nTPM
fallopian tube: 16 nTPM
adrenal gland: 13 nTPM
testis: 11 nTPM
choroid plexus: 10 nTPM
thyroid gland: 9.3 nTPM

Single-cell type

sertoli cells: 99 nCPM
erythrocyte progenitors: 96 nCPM
endometrial ciliated cells: 65 nCPM
fallopian tube ciliated cells: 58 nCPM
epididymal efferent duct ciliated cells: 48 nCPM
ependymal cells: 47 nCPM

Immune cell

memory B-cell: 2 nTPM
naive B-cell: 1 nTPM
memory CD4 T-cell: 0.9 nTPM
NK-cell: 0.7 nTPM
naive CD8 T-cell: 0.5 nTPM
naive CD4 T-cell: 0.4 nTPM

Brain region

choroid plexus: 15 nTPM
midbrain: 7.5 nTPM
medulla oblongata: 7.3 nTPM
spinal cord: 5 nTPM
pons: 2.8 nTPM
white matter: 2.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.49
gnomAD pLI: 0
gnomAD missense Z: 0.27
DepMap mean gene effect: 0.14
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NUP62CL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUP62CL as an antibody target. Whether an autoantibody or antibody against NUP62CL could matter depends on whether native NUP62CL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUP62CL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NUP62CL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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