Seroatlas · Human Serome Atlas

NUP210L

Nuclear pore membrane glycoprotein 210-like

Also known as: P210L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5VU65
Gene
NUP210L
Ensembl
ENSG00000143552
Chromosome
1
Canonical length
1888 aa
Protein class
Cancer-related genes, Metabolic proteins, Predicted membrane proteins
Subcellular location
Nuclear bodies,Cytosol

OverviewNCBI Gene

Predicted to act upstream of or within Sertoli cell development and spermatid development. Predicted to be located in membrane. Predicted to be part of nuclear pore. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1888 residues, UniProt reviewed canonical sequence.

>Q5VU65|NUP210L
     1  MTGCPASSRR RGFGLFFFLR LHRLLLLFLV LRGTLANKLN VPQVLLPFGR EPGRVPFLLE
    61  AQRGCYTWHS THHDAVTVEP LYENGTLCSQ KAVLIAESTQ PIRLSSIILA REIVTDHELR
   121  CDVKVDVINS IEIVSRAREL YVDDSPLELM VRALDAEGNT FSSLAGMMFE WSIAQDNESA
   181  REELSSKIRI LKYSEAEYAP PIYIAEMEKE EKQGDVILVS GIRTGAAVVK VRIHEPFYKK
   241  VAAALIRLLV LENIFLIPSH DIYLLVGTYI KYQVAKMVQG RVTEVKFPLE HYILELQDHR
   301  VALNGSHSEK VAILDDKTAM VTASQLGQTN LVFVHKNVHM RSVSGLPNCT IYVVEPGFLG
   361  FTVQPGNRWS LEVGQVYVIT VDVFDKSSTK VYISDNLRIT YDFPKEYFEE QLTTVNGSYH
   421  IVKALKDGVV VINASLTSII YQNKDIQPIK FLIKHQQEVK IYFPIMLTPK FLAFPHHPMG
   481  MLYRYKVQVE GGSGNFTWTS SNETVVIVTT KGVVTAGQVR GNSTVLARDV QNPFRYGEIK
   541  IHVLKLNKME LLPFHADVEI GQIIEIPIAM YHINKETKEA MAFTDCSHLS LDLNMDKQGV
   601  FTLLKEGIQR PGPMHCSSTH IAAKSLGHTL VTVSVNECDK YLESSATFAA YEPLKALNPV
   661  EVALVTWQSV KEMVFEGGPR PWILEPSRFF LELNAEKTEK IGIAQVWLPS KRKQNQYIYR
   721  IQCLDLGEQV LTFRIGNHPG VLNPSPAVEV LQVRFICAHP ASMSVTPVYK VPAGAQPCPL
   781  PQHNKWLIPV SRLRDTVLEL AVFDQHRRKF DNFSSLMLEW KSSNETLAHF EDYKSVEMVA
   841  KDDGSGQTRL HGHQILKVHQ IKGTVLIGVN FVGYSEKKSP KEISNLPRSV DVELLLVDDV
   901  TVVPENATIY NHPDVKETFS LVEGSGYFLV NSSEQGVVTI TYMEAESSVE LVPLHPGFFT
   961  LEVYDLCLAF LGPATAHLRV SDIQELELDL IDKVEIDKTV LVTVRVLGSS KRPFQNKYFR
  1021  NMELKLQLAS AIVTLTPMEQ QDEYSENYIL RATTIGQTTL VAIAKDKMGR KYTSTPRHIE
  1081  VFPPFRLLPE KMTLIPMNMM QVMSEGGPQP QSIVHFSISN QTVAVVNRRG QVTGKIVGTA
  1141  VVHGTIQTVN EDTGKVIVFS QDEVQIEVVQ LRAVRILAAA TRLITATKMP VYVMGVTSTQ
  1201  TPFSFSNANP GLTFHWSMSK RDVLDLVPRH SEVFLQLPVE HNFAMVVHTK AAGRTSIKVT
  1261  VHCMNSSSGQ FEGNLLELSD EVQILVFEKL QLFYPECQPE QILMPINSQL KLHTNREGAA
  1321  FVSSRVLKCF PNSSVIEEDG EGLLKAGSIA GTAVLEVTSI EPFGVNQTTI TGVQVAPVTY
  1381  LRVSSQPKLY TAQGRTLSAF PLGMSLTFTV QFYNSIGEKF HTHNTQLYLA LNRDDLLHIG
  1441  PGNKNYTYMA QAVNRGLTLV GLWDRRHPGM ADYIPVAVEH AIEPDTKLTF VGDIICFSTH
  1501  LVSQHGEPGI WMISANNILQ TDIVTGVGVA RSPGTAMIFH DIPGVVKTYR EVVVNASSRL
  1561  MLSYDLKTYL TNTLNSTVFK LFITTGRNGV NLKGFCTPNQ ALAITKVLLP ATLMLCHVQF
  1621  SNTLLDIPAS KVFQVHSDFS MEKGVYVCII KVRPQSEELL QALSVADTSV YGWATLVSER
  1681  SKNGMQRILI PFIPAFYINQ SELVLSHKQD IGEIRVLGVD RVLRKLEVIS SSPVLVVAGH
  1741  SHSPLTPGLA IYSVRVVNFT SFQQMASPVF INISCVLTSQ SEAVVVRAMK DKLGADHCED
  1801  SAILKRFTGS YQILLLTLFA VLASTASIFL AYNAFLNKIQ TVPVVYVPTL GTPQPGFFNS
  1861  TSSPPHFMSL QPPLAQSRLQ HWLWSIRH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUP210L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
25 nTPM

Expression across tissuesHPA

Tissue

  • testis: 25 nTPM
  • choroid plexus: 0.6 nTPM
  • retina: 0.4 nTPM
  • pituitary gland: 0.3 nTPM
  • seminal vesicle: 0.3 nTPM
  • smooth muscle: 0.2 nTPM

Single-cell type

  • early primary spermatocytes: 108 nCPM
  • endometrial luminal cells: 83 nCPM
  • differentiating spermatogonia: 56 nCPM
  • late primary spermatocytes: 55 nCPM
  • epididymal basal cells: 52 nCPM
  • endometrial glandular cells: 49 nCPM

Immune cell

  • neutrophil: 0.3 nTPM
  • eosinophil: 0.2 nTPM
  • naive CD4 T-cell: 0.1 nTPM
  • NK-cell: 0.1 nTPM
  • plasmacytoid DC: 0.1 nTPM
  • T-reg: 0.1 nTPM

Brain region

  • cerebellum: 7.4 nTPM
  • white matter: 6.8 nTPM
  • cerebral cortex: 4.3 nTPM
  • pons: 4.1 nTPM
  • basal ganglia: 3.9 nTPM
  • medulla oblongata: 3.8 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NUP210L.

Disease | AllUniProt

Conditions NUP210L is implicated in, by any mechanism.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 210 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Spermatogenic failure 97

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.38
gnomAD pLI
0
gnomAD missense Z
2.68
DepMap mean gene effect
-0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUP210L as an antibody target. Whether an autoantibody or antibody against NUP210L could matter depends on whether native NUP210L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUP210L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NUP210L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NUP210L. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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