NUDT8
Mitochondrial coenzyme A diphosphatase NUDT8
Also known as: FLJ41567, NUDT8_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8WV74
- Gene
- NUDT8
- Ensembl
- ENSG00000167799
- Chromosome
- 11
- Canonical length
- 236 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoli,Cytosol
OverviewNCBI Gene
Predicted to enable magnesium ion binding activity and manganese ion binding activity. Predicted to be involved in nucleoside phosphate catabolic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
236 residues, UniProt reviewed canonical sequence.
>Q8WV74|NUDT8
1 MLPDCLSAEG ELRCRRLLAG ATARLRARPA SAAVLVPLCS VRGVPALLYT LRSSRLTGRH
61 KGDVSFPGGK CDPADQDVVH TALRETREEL GLAVPEEHVW GLLRPVYDPQ KATVVPVLAG
121 VGPLDPQSLR PNSEEVDEVF ALPLAHLLQT QNQGYTHFCR GGHFRYTLPV FLHGPHRVWG
181 LTAVITEFAL QLLAPGTYQP RLAGLTCSGA EGLARPKQPL ASPCQASSTP GLNKGLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against NUDT8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.35
- Highest tissue expression
- 73 nTPM
Expression across tissuesHPA
Tissue
- heart muscle: 73 nTPM
- liver: 56 nTPM
- skeletal muscle: 55 nTPM
- esophagus: 54 nTPM
- tongue: 39 nTPM
- skin: 30 nTPM
Single-cell type
- esophageal suprabasal cells: 358 nCPM
- esophageal apical cells: 290 nCPM
- esophageal basal cells: 194 nCPM
- hepatocytes: 192 nCPM
- enterocytes: 124 nCPM
- suprabasal keratinocytes: 122 nCPM
Immune cell
- non-classical monocyte: 14 nTPM
- plasmacytoid DC: 12 nTPM
- NK-cell: 9.5 nTPM
- naive B-cell: 6.5 nTPM
- intermediate monocyte: 4.7 nTPM
- myeloid DC: 4.6 nTPM
Brain region
- cerebellum: 14 nTPM
- medulla oblongata: 12 nTPM
- thalamus: 12 nTPM
- white matter: 11 nTPM
- basal ganglia: 11 nTPM
- hypothalamus: 10 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.81
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.13
- DepMap mean gene effect
- -0.12
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- acetyl-CoA catabolic process
- butyryl-CoA catabolic process
- coenzyme A catabolic process
- malonyl-CoA catabolic process
- medium-chain fatty-acyl-CoA catabolic process
- propionyl-CoA catabolic process
- succinyl-CoA catabolic process
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of NUDT8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads NUDT8 as an antibody target. Whether an autoantibody or antibody against NUDT8 could matter depends on whether native NUDT8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
NUDT8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label NUDT8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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