Seroatlas · Human Serome Atlas

NUDT7

Peroxisomal coenzyme A diphosphatase NUDT7

Also known as: NUDT7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0C024
Gene: NUDT7
Ensembl: ENSG00000140876
Chromosome: 16
Canonical length: 238 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

238 residues, UniProt reviewed canonical sequence.

>P0C024|NUDT7
     1  MSRLGLPEEP VRNSLLDDAK ARLRKYDIGG KYSHLPYNKY SVLLPLVAKE GKLHLLFTVR
    61  SEKLRRAPGE VCFPGGKRDP TDMDDAATAL REAQEEVGLR PHQVEVVCCL VPCLIDTDTL
   121  ITPFVGLIDH NFQAQPNPAE VKDVFLVPLA YFLHPQVHDQ HYVTRLGHRF INHIFEYTNP
   181  EDGVTYQIKG MTANLAVLVA FIILEKKPTF EVQFNLNDVL ASSEELFLKV HKKATSRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUDT7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 66 nTPM

Expression across tissuesHPA

Tissue

liver: 66 nTPM
heart muscle: 35 nTPM
choroid plexus: 24 nTPM
adrenal gland: 22 nTPM
kidney: 21 nTPM
epididymis: 17 nTPM

Single-cell type

hepatocytes: 53 nCPM
choroid plexus epithelial cells: 41 nCPM
respiratory ciliated cells: 39 nCPM
late primary spermatocytes: 34 nCPM
oocytes: 32 nCPM
breast lactating cells: 32 nCPM

Immune cell

T-reg: 32 nTPM
naive B-cell: 20 nTPM
naive CD4 T-cell: 20 nTPM
non-classical monocyte: 18 nTPM
intermediate monocyte: 17 nTPM
memory CD8 T-cell: 15 nTPM

Brain region

choroid plexus: 32 nTPM
hypothalamus: 15 nTPM
cerebellum: 12 nTPM
thalamus: 12 nTPM
pons: 12 nTPM
basal ganglia: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.92
gnomAD pLI: 0
gnomAD missense Z: -0.83
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUDT7 as an antibody target. Whether an autoantibody or antibody against NUDT7 could matter depends on whether native NUDT7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUDT7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NUDT7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...