Seroatlas · Human Serome Atlas

NUDT6

Nucleoside diphosphate-linked moiety X motif 6

Also known as: FGF-AS, FGF2AS, gfg, gfg-1, NUDT6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P53370
Gene
NUDT6
Ensembl
ENSG00000170917
Chromosome
4
Canonical length
316 aa
Protein class
Predicted intracellular proteins
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene overlaps and lies on the opposite strand from FGF2 gene, and is thought to be the FGF2 antisense gene. The two genes are independently transcribed, and their expression shows an inverse relationship, suggesting that this antisense transcript may regulate FGF2 expression. This gene has also been shown to have hormone-regulatory and antiproliferative actions in the pituitary that are independent of FGF2 expression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

316 residues, UniProt reviewed canonical sequence.

>P53370|NUDT6
     1  MRQPLSWGRW RAMLARTYGP GPSAGYRWAS GAQGYVRNPP VGACDLQGEL DRFGGISVRL
    61  ARLDALDRLD AAAFQKGLQA AVQQWRSEGR TAVWLHIPIL QSRFIAPAAS LGFCFHHAES
   121  DSSTLTLWLR EGPSRLPGYA SHQVGVAGAV FDESTRKILV VQDRNKLKNM WKFPGGLSEP
   181  EEDIGDTAVR EVFEETGIKS EFRSVLSIRQ QHTNPGAFGK SDMYIICRLK PYSFTINFCQ
   241  EECLRCEWMD LNDLAKTENT TPITSRVARL LLYGYREGFD KIDLTVEELP AVYTGLFYKL
   301  YHKELPENYK TMKGID

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUDT6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • liver: 26 nTPM
  • kidney: 18 nTPM
  • heart muscle: 12 nTPM
  • choroid plexus: 12 nTPM
  • tongue: 10 nTPM
  • adrenal gland: 9.8 nTPM

Single-cell type

  • late primary spermatocytes: 62 nCPM
  • adipocytes: 58 nCPM
  • early spermatids: 30 nCPM
  • hepatocytes: 26 nCPM
  • fibro-adipogenic progenitors: 25 nCPM
  • microglia: 22 nCPM

Immune cell

  • myeloid DC: 4.4 nTPM
  • memory B-cell: 4 nTPM
  • intermediate monocyte: 2.8 nTPM
  • memory CD8 T-cell: 2.6 nTPM
  • non-classical monocyte: 2.5 nTPM
  • T-reg: 2.3 nTPM

Brain region

  • cerebral cortex: 25 nTPM
  • hypothalamus: 24 nTPM
  • basal ganglia: 23 nTPM
  • amygdala: 23 nTPM
  • hippocampal formation: 22 nTPM
  • midbrain: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.95
gnomAD pLI
0
gnomAD missense Z
-0.02
DepMap mean gene effect
-0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUDT6 as an antibody target. Whether an autoantibody or antibody against NUDT6 could matter depends on whether native NUDT6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUDT6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NUDT6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NUDT6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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