NUDT4B
Diphosphoinositol polyphosphate phosphohydrolase NUDT4B
Also known as: NUD4B_HUMAN, NUDT4P1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A024RBG1
- Gene
- NUDT4B
- Ensembl
- ENSG00000177144
- Chromosome
- 1
- Canonical length
- 181 aa
- Protein class
- Enzymes, Predicted intracellular proteins
- Subcellular location
- Cytosol
OverviewNCBI Gene
Predicted to enable pyrophosphatase activity. Predicted to be involved in diphosphoinositol polyphosphate metabolic process and nucleotide catabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
181 residues, UniProt reviewed canonical sequence.
>A0A024RBG1|NUDT4B
1 MMKFKPNQTR TYDREGFKKR AACLCFRSEQ EDEVLLVSSS RYPDQWIVPG GGMEPEEEPG
61 GAAVREVYEE AGVKGKLGRL LGIFEQNQDR KHRTYVYVLT VTEILEDWED SVNIGRKREW
121 FKVEDAIKVL QCHKPVHAEY LEKLKLGCSP ANGNSTVPSL PDNNALFVTA AQTSGLPSSV
181 RLocalizationUniProt · AlphaFold · HPA
Whether an antibody against NUDT4B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.36
- Highest tissue expression
- 12 nTPM
Expression across tissuesHPA
Tissue
- kidney: 12 nTPM
- heart muscle: 11 nTPM
- salivary gland: 11 nTPM
- bone marrow: 10 nTPM
- skeletal muscle: 9.4 nTPM
- ovary: 9 nTPM
Single-cell type
- loop of henle epithelial cells: 4.1 nCPM
- renal connecting tubule cells: 1.8 nCPM
- distal convoluted tubule cells: 1.7 nCPM
- renal collecting duct principal cells: 1.6 nCPM
- papillary tip epithelial cells: 0.9 nCPM
- proximal tubule cells: 0.8 nCPM
Immune cell
- eosinophil: 3.3 nTPM
- basophil: 1.2 nTPM
- intermediate monocyte: 1.1 nTPM
- classical monocyte: 0.9 nTPM
- NK-cell: 0.8 nTPM
- non-classical monocyte: 0.8 nTPM
Brain region
- cerebral cortex: 12 nTPM
- midbrain: 12 nTPM
- basal ganglia: 11 nTPM
- medulla oblongata: 9.9 nTPM
- choroid plexus: 9.2 nTPM
- white matter: 9.2 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about NUDT4B.
Disease | ImmuneIEDB
Conditions an epitope on NUDT4B was assayed in.
- skin melanoma T cell
OntologyGO
Biological processes
- adenosine 5'-(hexahydrogen pentaphosphate) catabolic process
- diadenosine hexaphosphate catabolic process
- diadenosine pentaphosphate catabolic process
- diphosphoinositol polyphosphate metabolic process
Molecular functions
- bis(5'-adenosyl)-hexaphosphatase activity
- bis(5'-adenosyl)-pentaphosphatase activity
- diphosphoinositol-polyphosphate diphosphatase activity
- endopolyphosphatase activity
- metal ion binding
- RNA binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads NUDT4B as an antibody target. Whether an autoantibody or antibody against NUDT4B could matter depends on whether native NUDT4B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
NUDT4B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label NUDT4B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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