Seroatlas · Human Serome Atlas

NUDT4

Diphosphoinositol polyphosphate phosphohydrolase 2

Also known as: DIPP2, DIPP2alpha, DIPP2beta, HDCMB47P, KIAA0487, NUDT4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NZJ9
Gene
NUDT4
Ensembl
ENSG00000173598
Chromosome
12
Canonical length
180 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

The protein encoded by this gene regulates the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to regulating intracellular trafficking. Several alternatively spliced transcript variants have been described, but the full-length nature of some variants has not been determined. Isoforms DIPP2alpha and DIPP2beta are distinguishable from each other solely by DIPP2beta possessing one additional amino acid due to intron boundary skidding in alternate splicing. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

180 residues, UniProt reviewed canonical sequence.

>Q9NZJ9|NUDT4
     1  MMKFKPNQTR TYDREGFKKR AACLCFRSEQ EDEVLLVSSS RYPDQWIVPG GGMEPEEEPG
    61  GAAVREVYEE AGVKGKLGRL LGIFENQDRK HRTYVYVLTV TEILEDWEDS VNIGRKREWF
   121  KVEDAIKVLQ CHKPVHAEYL EKLKLGCSPA NGNSTVPSLP DNNALFVTAA QTSGLPSSVR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUDT4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
154 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 154 nTPM
  • heart muscle: 148 nTPM
  • ovary: 116 nTPM
  • salivary gland: 116 nTPM
  • kidney: 109 nTPM
  • tongue: 100 nTPM

Single-cell type

  • cardiomyocytes: 591 nCPM
  • pituicytes/fscs: 252 nCPM
  • schwann cells: 237 nCPM
  • salivary acinar cells: 217 nCPM
  • distal convoluted tubule cells: 216 nCPM
  • loop of henle epithelial cells: 212 nCPM

Immune cell

  • eosinophil: 10 nTPM
  • basophil: 8.7 nTPM
  • NK-cell: 5.6 nTPM
  • MAIT T-cell: 4.8 nTPM
  • naive CD4 T-cell: 4.1 nTPM
  • memory B-cell: 3.9 nTPM

Brain region

  • cerebral cortex: 73 nTPM
  • basal ganglia: 67 nTPM
  • midbrain: 58 nTPM
  • hypothalamus: 56 nTPM
  • white matter: 54 nTPM
  • choroid plexus: 46 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.49
gnomAD pLI
0.8
gnomAD missense Z
1.94

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUDT4 as an antibody target. Whether an autoantibody or antibody against NUDT4 could matter depends on whether native NUDT4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUDT4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NUDT4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NUDT4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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