NUDT22
Uridine diphosphate glucose pyrophosphatase NUDT22
Also known as: MGC13045, NUD22_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9BRQ3
- Gene
- NUDT22
- Ensembl
- ENSG00000149761
- Chromosome
- 11
- Canonical length
- 303 aa
- Protein class
- Enzymes, Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
Enables UDP-sugar diphosphatase activity and metal ion binding activity. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
303 residues, UniProt reviewed canonical sequence.
>Q9BRQ3|NUDT22
1 MDPEVTLLLQ CPGGGLPQEQ IQAELSPAHD RRPLPGGDEA ITAIWETRLK AQPWLFDAPK
61 FRLHSATLAP IGSRGPQLLL RLGLTSYRDF LGTNWSSSAA WLRQQGATDW GDTQAYLADP
121 LGVGAALATA DDFLVFLRRS RQVAEAPGLV DVPGGHPEPQ ALCPGGSPQH QDLAGQLVVH
181 ELFSSVLQEI CDEVNLPLLT LSQPLLLGIA RNETSAGRAS AEFYVQCSLT SEQVRKHYLS
241 GGPEAHESTG IFFVETQNVQ RLLETEMWAE LCPSAKGAII LYNRVQGSPT GAALGSPALL
301 PPLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against NUDT22 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.27
- Highest tissue expression
- 49 nTPM
Expression across tissuesHPA
Tissue
- heart muscle: 49 nTPM
- liver: 46 nTPM
- kidney: 44 nTPM
- pancreas: 43 nTPM
- skeletal muscle: 40 nTPM
- spleen: 40 nTPM
Single-cell type
- cytotrophoblasts: 133 nCPM
- esophageal apical cells: 126 nCPM
- enterocytes: 115 nCPM
- esophageal suprabasal cells: 110 nCPM
- plasma cells: 102 nCPM
- cardiomyocytes: 102 nCPM
Immune cell
- plasmacytoid DC: 122 nTPM
- intermediate monocyte: 89 nTPM
- non-classical monocyte: 87 nTPM
- naive B-cell: 78 nTPM
- myeloid DC: 73 nTPM
- classical monocyte: 69 nTPM
Brain region
- choroid plexus: 20 nTPM
- thalamus: 19 nTPM
- medulla oblongata: 17 nTPM
- cerebellum: 17 nTPM
- hypothalamus: 17 nTPM
- spinal cord: 17 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.35
- gnomAD pLI
- 0
- gnomAD missense Z
- 1
- DepMap mean gene effect
- -0.04
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
- metal ion binding
- UDP-sugar diphosphatase activity
- GDP-mannose hydrolase activity
Cellular components
Protein domainsUniProt · Pfam · InterPro
- NUDIX hydrolase domain
- Uridine diphosphate glucose pyrophosphatase NUDT22/Nudix hydrolase 9-like
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads NUDT22 as an antibody target. Whether an autoantibody or antibody against NUDT22 could matter depends on whether native NUDT22 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
NUDT22 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label NUDT22 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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