Seroatlas · Human Serome Atlas

NUDT19

Acyl-coenzyme A diphosphatase NUDT19

Also known as: NUD19_HUMAN, RP2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8MXV4
Gene: NUDT19
Ensembl: ENSG00000213965
Chromosome: 19
Canonical length: 375 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Cytosol

OverviewNCBI Gene

Predicted to enable magnesium ion binding activity. Predicted to be involved in acyl-CoA metabolic process and coenzyme A catabolic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

375 residues, UniProt reviewed canonical sequence.

>A8MXV4|NUDT19
     1  MSSSLRPGPS RWRRAASIVL AAGWSRPETA TPPSRPPPAE GFRLLLLQRS PHQGFMPGAH
    61  VFSGGVLDAA DRSADWLGLF APHHGPPRFG LGPAPFSRTA FPSLPDTDDH KTDNTGTLPE
   121  DVAFRICAVR EAFEEAGVLL LRPRTSPPGP APGPGLALEP PPGLASWRDR VRQDPRHFLR
   181  LCAHLDCTPD IWALHNWSAW LTPFLRGTTR RFDTAFFLCC LREPPPVYPD LAEVVGYQWS
   241  SPSEATESFL SKEIWLPPPQ FYEVRRLANF ASLSDLHKFC LGRALEGLER WLPIILLTAD
   301  GMVHLLPGDE LYLEDSDFLE NLMSTEKKTE EIMKEGKQFH RIVTYHRHLY DIHVTVQPKY
   361  KHVYPKNSVV RKSHL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUDT19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 22 nTPM
tongue: 12 nTPM
adrenal gland: 10 nTPM
esophagus: 10 nTPM
heart muscle: 9.5 nTPM
skin: 8 nTPM

Single-cell type

parietal cells: 74 nCPM
megakaryocytes: 56 nCPM
rod photoreceptor cells: 55 nCPM
cardiomyocytes: 53 nCPM
neutrophil progenitors: 50 nCPM
esophageal apical cells: 44 nCPM

Immune cell

non-classical monocyte: 41 nTPM
intermediate monocyte: 35 nTPM
NK-cell: 31 nTPM
classical monocyte: 25 nTPM
T-reg: 23 nTPM
memory CD8 T-cell: 22 nTPM

Brain region

choroid plexus: 21 nTPM
hypothalamus: 13 nTPM
pons: 12 nTPM
white matter: 12 nTPM
cerebral cortex: 12 nTPM
medulla oblongata: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.98
gnomAD pLI: 0
gnomAD missense Z: -2.53
DepMap mean gene effect: 0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NUDT19 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

HSPD1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUDT19 as an antibody target. Whether an autoantibody or antibody against NUDT19 could matter depends on whether native NUDT19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUDT19 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NUDT19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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