Seroatlas · Human Serome Atlas

NUDT18

8-oxo-dGDP phosphatase NUDT18

Also known as: FLJ22494, MTH3, NUD18_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZVK8
Gene: NUDT18
Ensembl: ENSG00000275074
Chromosome: 8
Canonical length: 323 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. This protein contains a Nudix hydrolase domain and hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates. [provided by RefSeq, Sep 2012]

Canonical amino-acid sequenceUniProt

323 residues, UniProt reviewed canonical sequence.

>Q6ZVK8|NUDT18
     1  MASEGLAGAL ASVLAGQGSS VHSCDSAPAG EPPAPVRLRK NVCYVVLAVF LSEQDEVLLI
    61  QEAKRECRGS WYLPAGRMEP GETIVEALQR EVKEEAGLHC EPETLLSVEE RGPSWVRFVF
   121  LARPTGGILK TSKEADAESL QAAWYPRTSL PTPLRAHDIL HLVELAAQYR QQARHPLILP
   181  QELPCDLVCQ RLVATFTSAQ TVWVLVGTVG MPHLPVTACG LDPMEQRGGM KMAVLRLLQE
   241  CLTLHHLVVE IKGLLGLQHL GRDHSDGICL NVLVTVAFRS PGIQDEPPKV RGENFSWWKV
   301  MEEDLQSQLL QRLQGSSVVP VNR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUDT18 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

pancreas: 16 nTPM
epididymis: 12 nTPM
spleen: 9.9 nTPM
pituitary gland: 8.8 nTPM
choroid plexus: 8.5 nTPM
stomach: 8.5 nTPM

Single-cell type

enterocytes: 38 nCPM
epididymal principal cells: 34 nCPM
esophageal apical cells: 24 nCPM
late spermatids: 21 nCPM
esophageal suprabasal cells: 20 nCPM
epididymal clear cells: 18 nCPM

Immune cell

NK-cell: 4 nTPM
eosinophil: 3 nTPM
gdT-cell: 2.2 nTPM
MAIT T-cell: 2.1 nTPM
naive B-cell: 2 nTPM
naive CD4 T-cell: 2 nTPM

Brain region

pons: 13 nTPM
thalamus: 12 nTPM
hippocampal formation: 12 nTPM
cerebellum: 12 nTPM
cerebral cortex: 12 nTPM
medulla oblongata: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.62
gnomAD pLI: 0
gnomAD missense Z: 0.56

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUDT18 as an antibody target. Whether an autoantibody or antibody against NUDT18 could matter depends on whether native NUDT18 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUDT18 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NUDT18 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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