Seroatlas · Human Serome Atlas

NUDT17

m7GpppN-mRNA hydrolase NUDT17

Also known as: FLJ34433, NUD17_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0C025
Gene: NUDT17
Ensembl: ENSG00000186364
Chromosome: 1
Canonical length: 328 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable NADH pyrophosphatase activity. Predicted to be involved in NAD catabolic process; NADH metabolic process; and NADP catabolic process. Predicted to be active in peroxisome. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

328 residues, UniProt reviewed canonical sequence.

>P0C025|NUDT17
     1  MAEVRVQLLL SRRPESVSFA RSVCGLLGAG PGLGTWPIHC SLKRGRLVLS SRPFPGASAR
    61  LPLQRPPFCP FAALEERPRV PGAELPTDRG VDLGVAVILQ SSDKTVLLTR RARTLSVSPN
   121  LWVPPGGHVE LEEELLDGGL RELWEESGLH LPQGQFSWVP LGLWESAYPP RLSWGLPKYH
   181  HIVLYLLVIS QESQQQLQAR IQPNPNEVSA LMWLTPDVAA AVAAAEDGTE TPGLLPQDLP
   241  PSVLAVELEE DGRARPLVLH MSTLLRMIPT MAEDKERVST GTKFALKLWL QHLGRTPPPC
   301  KSAAYLDPGP AKEEWNMDPL PPNQGSGK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUDT17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 6.8 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 6.8 nTPM
cerebellum: 6.4 nTPM
amygdala: 5.7 nTPM
hypothalamus: 5.6 nTPM
cerebral cortex: 5.4 nTPM
hippocampal formation: 4.8 nTPM

Single-cell type

pdcs: 22 nCPM
differentiating spermatogonia: 18 nCPM
oocytes: 14 nCPM
hepatic stellate cells: 13 nCPM
early primary spermatocytes: 12 nCPM
epicardial cells: 11 nCPM

Immune cell

plasmacytoid DC: 27 nTPM
eosinophil: 18 nTPM
basophil: 8.4 nTPM
intermediate monocyte: 2.5 nTPM
non-classical monocyte: 1.7 nTPM
memory B-cell: 1.5 nTPM

Brain region

hypothalamus: 5.5 nTPM
cerebellum: 5 nTPM
basal ganglia: 4.3 nTPM
medulla oblongata: 4.1 nTPM
cerebral cortex: 3.9 nTPM
amygdala: 3.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.18
gnomAD pLI: 0
gnomAD missense Z: -0.73
DepMap mean gene effect: -0.26
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

peroxisome

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUDT17 as an antibody target. Whether an autoantibody or antibody against NUDT17 could matter depends on whether native NUDT17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUDT17 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NUDT17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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