Seroatlas · Human Serome Atlas

NUDT16

U8 snoRNA-decapping enzyme

Also known as: FLJ31265, NUD16_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96DE0
Gene: NUDT16
Ensembl: ENSG00000198585
Chromosome: 3
Canonical length: 195 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables several functions, including RNA binding activity; metal ion binding activity; and pyrophosphatase activity. Involved in RNA metabolic process and positive regulation of cell cycle process. Located in cytoplasm; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

195 residues, UniProt reviewed canonical sequence.

>Q96DE0|NUDT16
     1  MAGARRLELG EALALGSGWR HACHALLYAP DPGMLFGRIP LRYAILMQMR FDGRLGFPGG
    61  FVDTQDRSLE DGLNRELREE LGEAAAAFRV ERTDYRSSHV GSGPRVVAHF YAKRLTLEEL
   121  LAVEAGATRA KDHGLEVLGL VRVPLYTLRD GVGGLPTFLE NSFIGSAREQ LLEALQDLGL
   181  LQSGSISGLK IPAHH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUDT16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 56 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 56 nTPM
small intestine: 56 nTPM
midbrain: 49 nTPM
parathyroid gland: 46 nTPM
amygdala: 36 nTPM
spleen: 34 nTPM

Single-cell type

enterocytes: 307 nCPM
kupffer cells: 225 nCPM
alveolar cells type 2: 160 nCPM
hepatocytes: 114 nCPM
hofbauer cells: 106 nCPM
neutrophils: 99 nCPM

Immune cell

non-classical monocyte: 64 nTPM
intermediate monocyte: 55 nTPM
eosinophil: 47 nTPM
classical monocyte: 42 nTPM
neutrophil: 34 nTPM
myeloid DC: 33 nTPM

Brain region

spinal cord: 50 nTPM
thalamus: 49 nTPM
pons: 48 nTPM
medulla oblongata: 47 nTPM
white matter: 46 nTPM
basal ganglia: 45 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.9
gnomAD pLI: 0
gnomAD missense Z: 0.3
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

mRNA catabolic process
NAD-cap decapping
negative regulation of rRNA processing
positive regulation of cell cycle process
dITP catabolic process
sno(s)RNA catabolic process

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUDT16 as an antibody target. Whether an autoantibody or antibody against NUDT16 could matter depends on whether native NUDT16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUDT16 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NUDT16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...