Seroatlas · Human Serome Atlas

NUDT15

Nucleotide triphosphate diphosphatase NUDT15

Also known as: FLJ10956, MTH2, NUD15_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NV35
Gene: NUDT15
Ensembl: ENSG00000136159
Chromosome: 13
Canonical length: 164 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Apr 2016]

Canonical amino-acid sequenceUniProt

164 residues, UniProt reviewed canonical sequence.

>Q9NV35|NUDT15
     1  MTASAQPRGR RPGVGVGVVV TSCKHPRCVL LGKRKGSVGA GSFQLPGGHL EFGETWEECA
    61  QRETWEEAAL HLKNVHFASV VNSFIEKENY HYVTILMKGE VDVTHDSEPK NVEPEKNESW
   121  EWVPWEELPP LDQLFWGLRC LKEQGYDPFK EDLNHLVGYK GNHL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUDT15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

rectum: 21 nTPM
duodenum: 20 nTPM
colon: 19 nTPM
tongue: 17 nTPM
bone marrow: 17 nTPM
esophagus: 17 nTPM

Single-cell type

extravillous trophoblasts: 99 nCPM
esophageal basal cells: 85 nCPM
cardiomyocytes: 72 nCPM
migrating cytotrophoblasts: 69 nCPM
esophageal suprabasal cells: 59 nCPM
enteric transient amplifying cells: 51 nCPM

Immune cell

intermediate monocyte: 6.9 nTPM
naive CD8 T-cell: 5.8 nTPM
naive CD4 T-cell: 5.3 nTPM
classical monocyte: 4.8 nTPM
myeloid DC: 4.8 nTPM
non-classical monocyte: 4.8 nTPM

Brain region

hypothalamus: 13 nTPM
cerebellum: 13 nTPM
cerebral cortex: 12 nTPM
pons: 12 nTPM
midbrain: 11 nTPM
thalamus: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.41
gnomAD pLI: 0
gnomAD missense Z: 0.07
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

dGTP catabolic process
DNA protection
mitotic cell cycle
nucleobase-containing small molecule metabolic process
purine nucleotide catabolic process
regulation of proteasomal protein catabolic process
response to reactive oxygen species
xenobiotic catabolic process
nucleoside phosphate catabolic process

Molecular functions

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NUDT15 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PCNA

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUDT15 as an antibody target. Whether an autoantibody or antibody against NUDT15 could matter depends on whether native NUDT15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUDT15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NUDT15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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