Seroatlas · Human Serome Atlas

NUDT14

Uridine diphosphate glucose pyrophosphatase NUDT14

Also known as: NUD14_HUMAN, UGPP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95848
Gene: NUDT14
Ensembl: ENSG00000183828
Chromosome: 14
Canonical length: 222 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoli,Microtubules
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. This enzyme contains a Nudix hydrolase domain and is a UDPG pyrophosphatase that hydrolyzes UDPG to produce glucose 1-phosphate and UMP. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

222 residues, UniProt reviewed canonical sequence.

>O95848|NUDT14
     1  MERIEGASVG RCAASPYLRP LTLHYRQNGA QKSWDFMKTH DSVTVLLFNS SRRSLVLVKQ
    61  FRPAVYAGEV ERRFPGSLAA VDQDGPRELQ PALPGSAGVT VELCAGLVDQ PGLSLEEVAC
   121  KEAWEECGYH LAPSDLRRVA TYWSGVGLTG SRQTMFYTEV TDAQRSGPGG GLVEEGELIE
   181  VVHLPLEGAQ AFADDPDIPK TLGVIFGVSW FLSQVAPNLD LQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUDT14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 58 nTPM

Expression across tissuesHPA

Tissue

pituitary gland: 58 nTPM
cerebral cortex: 57 nTPM
amygdala: 48 nTPM
choroid plexus: 40 nTPM
pancreas: 38 nTPM
kidney: 35 nTPM

Single-cell type

enterocytes: 59 nCPM
hofbauer cells: 51 nCPM
parietal cells: 39 nCPM
microglia: 36 nCPM
melanocytes: 36 nCPM
epididymal efferent duct ciliated cells: 35 nCPM

Immune cell

non-classical monocyte: 69 nTPM
intermediate monocyte: 41 nTPM
classical monocyte: 41 nTPM
myeloid DC: 34 nTPM
total PBMC: 19 nTPM
plasmacytoid DC: 17 nTPM

Brain region

choroid plexus: 38 nTPM
cerebral cortex: 27 nTPM
white matter: 25 nTPM
hypothalamus: 25 nTPM
cerebellum: 22 nTPM
basal ganglia: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.64
gnomAD pLI: 0
gnomAD missense Z: -0.03
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUDT14 as an antibody target. Whether an autoantibody or antibody against NUDT14 could matter depends on whether native NUDT14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUDT14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NUDT14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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