Seroatlas · Human Serome Atlas

NUDT13

NAD(P)H pyrophosphatase NUDT13, mitochondrial

Also known as: DKFZp586P2219, NUD13_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86X67
Gene: NUDT13
Ensembl: ENSG00000166321
Chromosome: 10
Canonical length: 352 aa
Protein class: Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable NADH pyrophosphatase activity. Predicted to be involved in NADH metabolic process and NADP catabolic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

352 residues, UniProt reviewed canonical sequence.

>Q86X67|NUDT13
     1  MSLYCGIACR RKFFWCYRLL STYVTKTRYL FELKEDDDAC KKAQQTGAFY LFHSLAPLLQ
    61  TSAHQYLAPR HSLLELERLL GKFGQDAQRI EDSVLIGCSE QQEAWFALDL GLDSSFSISA
   121  SLHKPEMETE LKGSFIELRK ALFQLNARDA SLLSTAQALL RWHDAHQFCS RSGQPTKKNV
   181  AGSKRVCPSN NIIYYPQMAP VAITLVSDGT RCLLARQSSF PKGMYSALAG FCDIGESVEE
   241  TIRREVAEEV GLEVESLQYY ASQHWPFPSG SLMIACHATV KPGQTEIQVN LRELETAAWF
   301  SHDEVATALK RKGPYTQQQN GTFPFWLPPK LAISHQLIKE WVEKQTCSSL PA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUDT13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 6 nTPM

Expression across tissuesHPA

Tissue

liver: 6 nTPM
heart muscle: 4.1 nTPM
kidney: 4.1 nTPM
skeletal muscle: 4 nTPM
epididymis: 3.7 nTPM
adrenal gland: 3 nTPM

Single-cell type

epicardial cells: 223 nCPM
cardiomyocytes: 154 nCPM
myonuclei: 71 nCPM
thymic myoid cells: 44 nCPM
adipocytes: 40 nCPM
plasma cells: 37 nCPM

Immune cell

naive B-cell: 3.7 nTPM
NK-cell: 2.3 nTPM
T-reg: 1.7 nTPM
non-classical monocyte: 1.6 nTPM
memory B-cell: 1.3 nTPM
classical monocyte: 1.1 nTPM

Brain region

cerebellum: 12 nTPM
white matter: 9 nTPM
cerebral cortex: 8.8 nTPM
thalamus: 8.5 nTPM
pons: 8.4 nTPM
basal ganglia: 7.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.38
gnomAD pLI: 0
gnomAD missense Z: 0.51
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

nucleobase-containing small molecule interconversion

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUDT13 as an antibody target. Whether an autoantibody or antibody against NUDT13 could matter depends on whether native NUDT13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUDT13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NUDT13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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