NUDT11
Diphosphoinositol polyphosphate phosphohydrolase 3-beta
Also known as: DIPP3b, FLJ10628, hDIPP3beta, NUD11_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96G61
- Gene
- NUDT11
- Ensembl
- ENSG00000196368
- Chromosome
- X
- Canonical length
- 164 aa
- Protein class
- Enzymes, Metabolic proteins, Predicted intracellular proteins
- Subcellular location
- Cytosol
OverviewNCBI Gene
NUDT11 belongs to a subgroup of phosphohydrolases that preferentially attack diphosphoinositol polyphosphates (Hidaka et al., 2002 [PubMed 12105228]).[supplied by OMIM, Mar 2008]
Canonical amino-acid sequenceUniProt
164 residues, UniProt reviewed canonical sequence.
>Q96G61|NUDT11
1 MKCKPNQTRT YDPEGFKKRA ACLCFRSERE DEVLLVSSSR YPDRWIVPGG GMEPEEEPGG
61 AAVREVYEEA GVKGKLGRLL GVFEQNQDRK HRTYVYVLTV TELLEDWEDS VSIGRKREWF
121 KVEDAIKVLQ CHKPVHAEYL EKLKLGGSPT NGNSMAPSSP DSDPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against NUDT11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.32
- Highest tissue expression
- 34 nTPM
Expression across tissuesHPA
Tissue
- testis: 34 nTPM
- basal ganglia: 27 nTPM
- hypothalamus: 24 nTPM
- cerebral cortex: 23 nTPM
- amygdala: 15 nTPM
- ovary: 10 nTPM
Single-cell type
- sertoli cells: 51 nCPM
- undifferentiated spermatogonia: 28 nCPM
- epididymal basal cells: 27 nCPM
- pituicytes/fscs: 25 nCPM
- decidual stromal cells: 19 nCPM
- ovarian stromal cells: 19 nCPM
Immune cell
- gdT-cell: 1.2 nTPM
- naive CD8 T-cell: 0.9 nTPM
- NK-cell: 0.7 nTPM
- memory CD8 T-cell: 0.6 nTPM
- MAIT T-cell: 0.5 nTPM
- memory CD4 T-cell: 0.3 nTPM
Brain region
- hypothalamus: 45 nTPM
- basal ganglia: 26 nTPM
- cerebral cortex: 26 nTPM
- pons: 16 nTPM
- white matter: 14 nTPM
- midbrain: 13 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.26
- gnomAD pLI
- 0.1
- gnomAD missense Z
- 1.46
- DepMap mean gene effect
- -0.1
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- adenosine 5'-(hexahydrogen pentaphosphate) catabolic process
- diadenosine hexaphosphate catabolic process
- diadenosine pentaphosphate catabolic process
- diphosphoinositol polyphosphate metabolic process
Molecular functions
- bis(5'-adenosyl)-hexaphosphatase activity
- bis(5'-adenosyl)-pentaphosphatase activity
- diphosphoinositol-polyphosphate diphosphatase activity
- endopolyphosphatase activity
- metal ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads NUDT11 as an antibody target. Whether an autoantibody or antibody against NUDT11 could matter depends on whether native NUDT11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
NUDT11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label NUDT11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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