Seroatlas · Human Serome Atlas

NUDT10

Diphosphoinositol polyphosphate phosphohydrolase 3-alpha

Also known as: DIPP3a, hDIPP3alpha, NUD10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NFP7
Gene: NUDT10
Ensembl: ENSG00000122824
Chromosome: X
Canonical length: 164 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

This gene is a member of the nudix (nucleoside diphosphate linked moiety X)-type motif containing family. The encoded protein is a phosphohydrolase and may regulate the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to the regulation of intracellular trafficking. In some populations putative prostate cancer susceptibility alleles have been identified for this gene. Alternatively spliced transcript variants, which differ only in the 5' UTR, have been found for this gene. [provided by RefSeq, Feb 2015]

Canonical amino-acid sequenceUniProt

164 residues, UniProt reviewed canonical sequence.

>Q8NFP7|NUDT10
     1  MKCKPNQTRT YDPEGFKKRA ACLCFRSERE DEVLLVSSSR YPDRWIVPGG GMEPEEEPGG
    61  AAVREVYEEA GVKGKLGRLL GVFEQNQDPK HRTYVYVLTV TELLEDWEDS VSIGRKREWF
   121  KVEDAIKVLQ CHKPVHAEYL EKLKLGGSPT NGNSMAPSSP DSDP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUDT10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

testis: 25 nTPM
ovary: 17 nTPM
hypothalamus: 16 nTPM
epididymis: 15 nTPM
prostate: 14 nTPM
seminal vesicle: 14 nTPM

Single-cell type

sertoli cells: 31 nCPM
epididymal basal cells: 30 nCPM
peritubular myoid cells: 26 nCPM
ovarian stromal cells: 21 nCPM
granulosa cells: 11 nCPM
late spermatids: 8.4 nCPM

Immune cell

NK-cell: 0.3 nTPM
classical monocyte: 0.1 nTPM
memory B-cell: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM
basophil: 0 nTPM
eosinophil: 0 nTPM

Brain region

hypothalamus: 22 nTPM
basal ganglia: 22 nTPM
white matter: 18 nTPM
cerebral cortex: 17 nTPM
pons: 13 nTPM
midbrain: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.24
gnomAD pLI: 0.11
gnomAD missense Z: 0.98
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUDT10 as an antibody target. Whether an autoantibody or antibody against NUDT10 could matter depends on whether native NUDT10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUDT10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NUDT10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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