NUDT1

Protein identityUniProt · HPA

UniProt accession

P36639

Gene

NUDT1

Ensembl

ENSG00000106268

Chromosome

7

Canonical length

156 aa

Protein class

Cancer-related genes, Enzymes, Predicted intracellular proteins

Subcellular location

Cytosol

OverviewNCBI Gene

Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A rare single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described. [provided by RefSeq, Dec 2018]

Canonical amino-acid sequenceUniProt

156 residues, UniProt reviewed canonical sequence.

>P36639|NUDT1
     1  MGASRLYTLV LVLQPQRVLL GMKKRGFGAG RWNGFGGKVQ EGETIEDGAR RELQEESGLT
    61  VDALHKVGQI VFEFVGEPEL MDVHVFCTDS IQGTPVESDE MRPCWFQLDQ IPFKDMWPDD
   121  SYWFPLLLQK KKFHGYFKFQ GQDTILDYTL REVDTV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUDT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.27

Highest tissue expression

73 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.94

gnomAD pLI

0

gnomAD missense Z

-0.61

DepMap mean gene effect

0

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• DNA protection
• DNA repair
• response to oxidative stress
• purine nucleoside catabolic process

Molecular functions

• 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
• 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
• ATP diphosphatase activity
• hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
• metal ion binding
• snoRNA binding
• 2-hydroxy-ATP hydrolase activity
• 2-hydroxy-dATP hydrolase activity
• dATP diphosphatase activity
• N6-methyl-(d)ATP hydrolase activity
• O6-methyl-dGTP hydrolase activity

Cellular components

• cytoplasm
• cytosol
• mitochondrial matrix
• mitochondrion
• nucleus

Protein domainsUniProt · Pfam · InterPro

• NUDIX hydrolase domain
• NUDIX hydrolase-like domain superfamily
• NUDIX hydrolase, conserved site
• NUDIX hydrolase
• NUDIX domain
• Oxidized purine nucleoside triphosphate

KeywordsUniProt

• Alternative initiation
• Cytoplasm
• Hydrolase
• Magnesium
• Metal-binding
• Mitochondrion
• Nucleus
• RNA-binding
• Transit peptide

InteractionsUniProt · HPA

Protein binding partners of NUDT1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ACY1