Seroatlas · Human Serome Atlas

NUAK2

NUAK family SNF1-like kinase 2

Also known as: FLJ90349, NUAK2_HUMAN, SNARK

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H093
Gene: NUAK2
Ensembl: ENSG00000163545
Chromosome: 1
Canonical length: 628 aa
Protein class: Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted membrane proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in several processes, including cellular response to glucose starvation; protein phosphorylation; and regulation of hippo signaling. Located in nuclear speck. Implicated in anencephaly. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

628 residues, UniProt reviewed canonical sequence.

>Q9H093|NUAK2
     1  MESLVFARRS GPTPSAAELA RPLAEGLIKS PKPLMKKQAV KRHHHKHNLR HRYEFLETLG
    61  KGTYGKVKKA RESSGRLVAI KSIRKDKIKD EQDLMHIRRE IEIMSSLNHP HIIAIHEVFE
   121  NSSKIVIVME YASRGDLYDY ISERQQLSER EARHFFRQIV SAVHYCHQNR VVHRDLKLEN
   181  ILLDANGNIK IADFGLSNLY HQGKFLQTFC GSPLYASPEI VNGKPYTGPE VDSWSLGVLL
   241  YILVHGTMPF DGHDHKILVK QISNGAYREP PKPSDACGLI RWLLMVNPTR RATLEDVASH
   301  WWVNWGYATR VGEQEAPHEG GHPGSDSARA SMADWLRRSS RPLLENGAKV CSFFKQHAPG
   361  GGSTTPGLER QHSLKKSRKE NDMAQSLHSD TADDTAHRPG KSNLKLPKGI LKKKVSASAE
   421  GVQEDPPELS PIPASPGQAA PLLPKKGILK KPRQRESGYY SSPEPSESGE LLDAGDVFVS
   481  GDPKEQKPPQ ASGLLLHRKG ILKLNGKFSQ TALELAAPTT FGSLDELAPP RPLARASRPS
   541  GAVSEDSILS SESFDQLDLP ERLPEPPLRG CVSVDNLTGL EEPPSEGPGS CLRRWRQDPL
   601  GDSCFSLTDC QEVTATYRQA LRVCSKLT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUAK2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 55 nTPM

Expression across tissuesHPA

Tissue

esophagus: 55 nTPM
vagina: 43 nTPM
cervix: 38 nTPM
kidney: 28 nTPM
skin: 22 nTPM
duodenum: 16 nTPM

Single-cell type

esophageal apical cells: 561 nCPM
epididymal efferent duct absorptive cells: 215 nCPM
pancreatic duct cells: 144 nCPM
ocular epithelial cells: 129 nCPM
esophageal suprabasal cells: 105 nCPM
epididymal efferent duct ciliated cells: 102 nCPM

Immune cell

neutrophil: 121 nTPM
eosinophil: 40 nTPM
naive B-cell: 39 nTPM
memory B-cell: 38 nTPM
naive CD4 T-cell: 28 nTPM
naive CD8 T-cell: 22 nTPM

Brain region

cerebellum: 10 nTPM
white matter: 9.2 nTPM
choroid plexus: 7.6 nTPM
medulla oblongata: 5.6 nTPM
thalamus: 5.4 nTPM
pons: 5.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NUAK2.

Disease | AllUniProt

Conditions NUAK2 is implicated in, by any mechanism.

Anencephaly 2 (ANPH2) MIM:619452

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 117 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Anencephaly 2

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.77
gnomAD pLI: 0
gnomAD missense Z: 1.18
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUAK2 as an antibody target. Whether an autoantibody or antibody against NUAK2 could matter depends on whether native NUAK2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUAK2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NUAK2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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