Seroatlas · Human Serome Atlas

NTMT2

N-terminal Xaa-Pro-Lys N-methyltransferase 2

Also known as: C1orf184, HOMT1B, METTL11B, NTM1B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VVY1
Gene: NTMT2
Ensembl: ENSG00000203740
Chromosome: 1
Canonical length: 283 aa
Protein class: Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

Enables N-terminal protein N-methyltransferase activity. Involved in N-terminal protein amino acid methylation. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

283 residues, UniProt reviewed canonical sequence.

>Q5VVY1|NTMT2
     1  MAHRGAHFAF RSRWQKTDDE LCRHSMSFIL HKAIRNDFFQ SYLYLLEKIP LVKLYALTSQ
    61  VINGEMQFYA RAKLFYQEVP ATEEGMMGNF IELSSPDIQA SQKFLRKFVG GPGRAGTDCA
   121  LDCGSGIGRV SKHVLLPVFN SVELVDMMES FLLEAQNYLQ VKGDKVESYH CYSLQEFTPP
   181  FRRYDVIWIQ WVSGHLTDKD LLAFLSRCRD GLKENGIIIL KDNVAREGCI LDLSDSSVTR
   241  DMDILRSLIR KSGLVVLGQE KQDGFPEQCI PVWMFALHSD RHS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NTMT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 1.6 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 1.6 nTPM
skeletal muscle: 0.9 nTPM
testis: 0.2 nTPM
basal ganglia: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM

Single-cell type

cardiomyocytes: 12 nCPM
myonuclei: 3 nCPM
undifferentiated spermatogonia: 2.9 nCPM
leydig cells: 1.3 nCPM
late primary spermatocytes: 1.1 nCPM
sertoli cells: 1.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 0.2 nTPM
hypothalamus: 0.2 nTPM
white matter: 0.2 nTPM
amygdala: 0.1 nTPM
cerebellum: 0.1 nTPM
cerebral cortex: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.11
gnomAD pLI: 0
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

N-terminal protein amino acid methylation

Molecular functions

N-terminal protein N-methyltransferase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NTMT2 as an antibody target. Whether an autoantibody or antibody against NTMT2 could matter depends on whether native NTMT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NTMT2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NTMT2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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