Seroatlas · Human Serome Atlas

NTM

Neurotrimin

Also known as: CEPU-1, HNT, IGLON2, NTRI, NTRI_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9P121
Gene
NTM
Ensembl
ENSG00000182667
Chromosome
11
Canonical length
344 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Secretome location
Intracellular and membrane

OverviewNCBI Gene

This gene encodes a member of the IgLON (LAMP, OBCAM, Ntm) family of immunoglobulin (Ig) domain-containing glycosylphosphatidylinositol (GPI)-anchored cell adhesion molecules. The encoded protein may promote neurite outgrowth and adhesion via a homophilic mechanism. This gene is closely linked to a related family member, opioid binding protein/cell adhesion molecule-like (OPCML), on chromosome 11. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]

Canonical amino-acid sequenceUniProt

344 residues, UniProt reviewed canonical sequence.

>Q9P121|NTM
     1  MGVCGYLFLP WKCLVVVSLR LLFLVPTGVP VRSGDATFPK AMDNVTVRQG ESATLRCTID
    61  NRVTRVAWLN RSTILYAGND KWCLDPRVVL LSNTQTQYSI EIQNVDVYDE GPYTCSVQTD
   121  NHPKTSRVHL IVQVSPKIVE ISSDISINEG NNISLTCIAT GRPEPTVTWR HISPKAVGFV
   181  SEDEYLEIQG ITREQSGDYE CSASNDVAAP VVRRVKVTVN YPPYISEAKG TGVPVGQKGT
   241  LQCEASAVPS AEFQWYKDDK RLIEGKKGVK VENRPFLSKL IFFNVSEHDY GNYTCVASNK
   301  LGHTNASIML FGPGAVSEVS NGTSRRAGCV WLLPLLVLHL LLKF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NTM can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
83 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 83 nTPM
  • retina: 67 nTPM
  • cerebral cortex: 64 nTPM
  • amygdala: 35 nTPM
  • basal ganglia: 35 nTPM
  • spinal cord: 32 nTPM

Single-cell type

  • rod photoreceptor cells: 4,173 nCPM
  • astrocytes: 3,562 nCPM
  • cone photoreceptor cells: 2,979 nCPM
  • bergmann glia: 2,846 nCPM
  • oligodendrocyte progenitor cells: 2,832 nCPM
  • oligodendrocytes: 1,947 nCPM

Immune cell

  • plasmacytoid DC: 18 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebellum: 169 nTPM
  • cerebral cortex: 156 nTPM
  • white matter: 146 nTPM
  • thalamus: 142 nTPM
  • medulla oblongata: 124 nTPM
  • pons: 123 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.65
gnomAD pLI
0.06
gnomAD missense Z
1.2
DepMap mean gene effect
0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NTM as an antibody target. Whether an autoantibody or antibody against NTM could matter depends on whether native NTM is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NTM is annotated at the cell surface, where native NTM is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NTM as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NTM. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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