Seroatlas · Human Serome Atlas

NTAN1

Protein N-terminal asparagine amidohydrolase

Also known as: NTAN1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96AB6
Gene: NTAN1
Ensembl: ENSG00000157045
Chromosome: 16
Canonical length: 310 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

The protein encoded by this gene functions in a step-wise process of protein degradation through the N-end rule pathway. This protein acts as a tertiary destabilizing enzyme that deamidates N-terminal L-Asn residues on proteins to produce N-terminal L-Asp. L-Asp substrates are subsequently conjugated to L-Arg, which is recognized by specific E3 ubiquitin ligases and targeted to the proteasome. Pseudogenes of this gene are located on the long arms of chromosomes 8, 10 and 12. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

310 residues, UniProt reviewed canonical sequence.

>Q96AB6|NTAN1
     1  MPLLVEGRRV RLPQSAGDLV RAHPPLEERA RLLRGQSVQQ VGPQGLLYVQ QRELAVTSPK
    61  DGSISILGSD DATTCHIVVL RHTGNGATCL THCDGTDTKA EVPLIMNSIK SFSDHAQCGR
   121  LEVHLVGGFS DDRQLSQKLT HQLLSEFDRQ EDDIHLVTLC VTELNDREEN ENHFPVIYGI
   181  AVNIKTAEIY RASFQDRGPE EQLRAARTLA GGPMISIYDA ETEQLRIGPY SWTPFPHVDF
   241  WLHQDDKQIL ENLSTSPLAE PPHFVEHIRS TLMFLKKHPS PAHTLFSGNK ALLYKKNEDG
   301  LWEKISSPGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NTAN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 36 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 36 nTPM
colon: 28 nTPM
blood vessel: 27 nTPM
breast: 26 nTPM
urinary bladder: 25 nTPM
skeletal muscle: 23 nTPM

Single-cell type

oocytes: 92 nCPM
lymphatic endothelial cells: 48 nCPM
kupffer cells: 42 nCPM
platelets: 41 nCPM
urothelial cells: 37 nCPM
megakaryocytes: 31 nCPM

Immune cell

eosinophil: 18 nTPM
T-reg: 5.9 nTPM
plasmacytoid DC: 5.8 nTPM
basophil: 4.9 nTPM
memory B-cell: 4.2 nTPM
naive CD4 T-cell: 3.9 nTPM

Brain region

pons: 8.5 nTPM
midbrain: 8.4 nTPM
basal ganglia: 7.8 nTPM
medulla oblongata: 7.7 nTPM
cerebellum: 7.6 nTPM
hypothalamus: 7.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.1
gnomAD pLI: 0
gnomAD missense Z: 0.4
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein-N-terminal asparagine amidohydrolase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Protein N-terminal asparagine amidohydrolase
Protein N-terminal asparagine amidohydrolase

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NTAN1 as an antibody target. Whether an autoantibody or antibody against NTAN1 could matter depends on whether native NTAN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NTAN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NTAN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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