NT5M
5'(3')-deoxyribonucleotidase, mitochondrial
Also known as: dNT-2, dNT2, mdN, NT5M_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9NPB1
- Gene
- NT5M
- Ensembl
- ENSG00000205309
- Chromosome
- 17
- Canonical length
- 228 aa
- Protein class
- Metabolic proteins, Predicted intracellular proteins
- Quaternary structure
- Homodimer
OverviewNCBI Gene
This gene encodes a 5' nucleotidase that localizes to the mitochondrial matrix. This enzyme dephosphorylates the 5'- and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
228 residues, UniProt reviewed canonical sequence.
>Q9NPB1|NT5M
1 MIRLGGWCAR RLCSAAVPAG RRGAAGGLGL AGGRALRVLV DMDGVLADFE GGFLRKFRAR
61 FPDQPFIALE DRRGFWVSEQ YGRLRPGLSE KAISIWESKN FFFELEPLPG AVEAVKEMAS
121 LQNTDVFICT SPIKMFKYCP YEKYAWVEKY FGPDFLEQIV LTRDKTVVSA DLLIDDRPDI
181 TGAEPTPSWE HVLFTACHNQ HLQLQPPRRR LHSWADDWKA ILDSKRPCLocalizationUniProt · AlphaFold · HPA
Whether an antibody against NT5M can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.34
- Highest tissue expression
- 12 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 12 nTPM
- cerebral cortex: 11 nTPM
- cerebellum: 8.5 nTPM
- basal ganglia: 7.5 nTPM
- amygdala: 7.4 nTPM
- heart muscle: 7.3 nTPM
Single-cell type
- platelets: 723 nCPM
- megakaryocytes: 223 nCPM
- megakaryocyte progenitors: 90 nCPM
- megakaryocyte-erythroid progenitors: 72 nCPM
- hematopoietic stem cells: 61 nCPM
- erythrocyte progenitors: 42 nCPM
Immune cell
- eosinophil: 1.3 nTPM
- total PBMC: 1 nTPM
- memory CD8 T-cell: 0.5 nTPM
- MAIT T-cell: 0.4 nTPM
- myeloid DC: 0.2 nTPM
- basophil: 0 nTPM
Brain region
- cerebral cortex: 11 nTPM
- thalamus: 9.3 nTPM
- pons: 7.5 nTPM
- cerebellum: 7.4 nTPM
- amygdala: 7.3 nTPM
- white matter: 7.2 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.86
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.18
- DepMap mean gene effect
- 0
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads NT5M as an antibody target. Whether an autoantibody or antibody against NT5M could matter depends on whether native NT5M is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
NT5M is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label NT5M as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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