Seroatlas · Human Serome Atlas

NT5DC3

5'-nucleotidase domain-containing protein 3

Also known as: FLJ11266, NT5D3_HUMAN, TU12B1-TY

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86UY8
Gene: NT5DC3
Ensembl: ENSG00000111696
Chromosome: 12
Canonical length: 548 aa
Protein class: Metabolic proteins, Predicted intracellular proteins
Subcellular location: Mitochondria,Cytosol

OverviewNCBI Gene

Predicted to enable 5'-nucleotidase activity. Located in mitochondrion. Part of receptor complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

548 residues, UniProt reviewed canonical sequence.

>Q86UY8|NT5DC3
     1  MTMAAAAVVA RGAGARAATA AALRGGCGTA ARGRPCAGPA RPLCTAPGTA PDMKRYLWER
    61  YREAKRSTEE LVPSIMSNLL NPDAIFSNNE MSLSDIEIYG FDYDYTLVFY SKHLHTLIFN
   121  AARDLLINEH RYPAEIRKYE YDPNFAIRGL HYDVQRAVLM KIDAFHYIQL GTVYRGLSVV
   181  PDEEVIEMYE GSHVPLEQMS DFYGKSSHGN TMKQFMDIFS LPEMTLLSCV NEYFLKNNID
   241  YEPVHLYKDV KDSIRDVHIK GIMYRAIEAD IEKYICYAEQ TRAVLAKLAD HGKKMFLITN
   301  SPSSFVDKGM SYIVGKDWRD LFDVVIVQAE KPNFFNDKRR PFRKMNEKGV LLWDKIHKLQ
   361  KGQIYKQGNL YEFLKLTGWR GSRVLYFGDH IYSDLADLTL KHGWRTGAII PELRSELKIM
   421  NTEQYIQTMT WLQTLTGLLE QMQVHRDAES QLVLQEWKKE RKEMREMTKS FFNAQFGSLF
   481  RTDQNPTYFL RRLSRFADIY MASLSCLLNY DVSHTFYPRR TPLQHELPAW SERPPTFGTP
   541  LLQEAQAK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NT5DC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 74 nTPM

Expression across tissuesHPA

Tissue

colon: 74 nTPM
urinary bladder: 22 nTPM
blood vessel: 21 nTPM
endometrium: 20 nTPM
bone marrow: 17 nTPM
cervix: 12 nTPM

Single-cell type

salivary basal cells: 163 nCPM
neutrophil progenitors: 161 nCPM
salivary acinar cells: 136 nCPM
smooth muscle cells: 130 nCPM
endometrial glandular cells: 122 nCPM
salivary myoepithelial cells: 119 nCPM

Immune cell

plasmacytoid DC: 1.9 nTPM
myeloid DC: 1.5 nTPM
naive B-cell: 1.4 nTPM
memory B-cell: 1.3 nTPM
MAIT T-cell: 1.2 nTPM
memory CD4 T-cell: 0.8 nTPM

Brain region

hippocampal formation: 65 nTPM
cerebral cortex: 49 nTPM
amygdala: 45 nTPM
basal ganglia: 41 nTPM
hypothalamus: 34 nTPM
thalamus: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.81
gnomAD pLI: 0
gnomAD missense Z: 1.82
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NT5DC3 as an antibody target. Whether an autoantibody or antibody against NT5DC3 could matter depends on whether native NT5DC3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NT5DC3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NT5DC3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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