Seroatlas · Human Serome Atlas

NT5DC2

5'-nucleotidase domain-containing protein 2

Also known as: FLJ12442, NT5D2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H857
Gene: NT5DC2
Ensembl: ENSG00000168268
Chromosome: 3
Canonical length: 520 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable 5'-nucleotidase activity. Predicted to be involved in negative regulation of dopamine biosynthetic process; negative regulation of oxidoreductase activity; and negative regulation of peptidyl-serine phosphorylation. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

520 residues, UniProt reviewed canonical sequence.

>Q9H857|NT5DC2
     1  MRVESGSAQE RGILLESLST LLEKTTASHE GRAPGNRELT DLLPPEVCSL LNPAAIYANN
    61  EISLRDVEVY GFDYDYTLAQ YADALHPEIF STARDILIEH YKYPEGIRKY DYNPSFAIRG
   121  LHYDIQKSLL MKIDAFHYVQ LGTAYRGLQP VPDEEVIELY GGTQHIPLYQ MSGFYGKGPS
   181  IKQFMDIFSL PEMALLSCVV DYFLGHSLEF DQAHLYKDVT DAIRDVHVKG LMYQWIEQDM
   241  EKYILRGDET FAVLSRLVAH GKQLFLITNS PFSFVDKGMR HMVGPDWRQL FDVVIVQADK
   301  PSFFTDRRKP FRKLDEKGSL QWDRITRLEK GKIYRQGNLF DFLRLTEWRG PRVLYFGDHL
   361  YSDLADLMLR HGWRTGAIIP ELEREIRIIN TEQYMHSLTW QQALTGLLER MQTYQDAESR
   421  QVLAAWMKER QELRCITKAL FNAQFGSIFR TFHNPTYFSR RLVRFSDLYM ASLSCLLNYR
   481  VDFTFYPRRT PLQHEAPLWM DQLCTGCMKT PFLGDMAHIR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NT5DC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 109 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 109 nTPM
blood vessel: 87 nTPM
prostate: 71 nTPM
adrenal gland: 69 nTPM
esophagus: 66 nTPM
cerebellum: 53 nTPM

Single-cell type

peritubular myoid cells: 137 nCPM
vascular smooth muscle cells: 93 nCPM
hepatic stellate cells: 78 nCPM
adrenal medulla cells: 75 nCPM
pericytes: 73 nCPM
plasma cells: 64 nCPM

Immune cell

plasmacytoid DC: 1.1 nTPM
myeloid DC: 0.8 nTPM
memory B-cell: 0.5 nTPM
classical monocyte: 0.3 nTPM
MAIT T-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM

Brain region

pons: 100 nTPM
midbrain: 62 nTPM
choroid plexus: 54 nTPM
medulla oblongata: 54 nTPM
cerebellum: 44 nTPM
hypothalamus: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.72
gnomAD pLI: 0
gnomAD missense Z: 1.04
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of catecholamine metabolic process
negative regulation of oxidoreductase activity
negative regulation of peptidyl-serine phosphorylation
negative regulation of dopamine biosynthetic process

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NT5DC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NT5DC2 as an antibody target. Whether an autoantibody or antibody against NT5DC2 could matter depends on whether native NT5DC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NT5DC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NT5DC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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