Seroatlas · Human Serome Atlas

NT5DC1

5'-nucleotidase domain-containing protein 1

Also known as: dJ486I3.1, MGC24302, NT5C2L1, NT5D1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5TFE4
Gene: NT5DC1
Ensembl: ENSG00000178425
Chromosome: 6
Canonical length: 455 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

While the exact function of the protein encoded by this gene is not known, it belongs to the 5'(3')-deoxyribonucleotidase family. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

455 residues, UniProt reviewed canonical sequence.

>Q5TFE4|NT5DC1
     1  MAQHFSLAAC DVVGFDLDHT LCRYNLPESA PLIYNSFAQF LVKEKGYDKE LLNVTPEDWD
    61  FCCKGLALDL EDGNFLKLAN NGTVLRASHG TKMMTPEVLA EAYGKKEWKH FLSDTGMACR
   121  SGKYYFYDNY FDLPGALLCA RVVDYLTKLN NGQKTFDFWK DIVAAIQHNY KMSAFKENCG
   181  IYFPEIKRDP GRYLHSCPES VKKWLRQLKN AGKILLLITS SHSDYCRLLC EYILGNDFTD
   241  LFDIVITNAL KPGFFSHLPS QRPFRTLEND EEQEALPSLD KPGWYSQGNA VHLYELLKKM
   301  TGKPEPKVVY FGDSMHSDIF PARHYSNWET VLILEELRGD EGTRSQRPEE SEPLEKKGKY
   361  EGPKAKPLNT SSKKWGSFFI DSVLGLENTE DSLVYTWSCK RISTYSTIAI PSIEAIAELP
   421  LDYKFTRFSS SNSKTAGYYP NPPLVLSSDE TLISK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NT5DC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 131 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 131 nTPM
liver: 40 nTPM
duodenum: 28 nTPM
prostate: 27 nTPM
thyroid gland: 27 nTPM
kidney: 26 nTPM

Single-cell type

choroid plexus epithelial cells: 1,727 nCPM
oligodendrocytes: 444 nCPM
prostatic glandular cells: 359 nCPM
gonadotrophs: 261 nCPM
distal convoluted tubule cells: 231 nCPM
sertoli cells: 228 nCPM

Immune cell

memory B-cell: 42 nTPM
eosinophil: 33 nTPM
T-reg: 33 nTPM
MAIT T-cell: 32 nTPM
naive B-cell: 30 nTPM
memory CD4 T-cell: 30 nTPM

Brain region

choroid plexus: 258 nTPM
white matter: 91 nTPM
medulla oblongata: 60 nTPM
basal ganglia: 59 nTPM
pons: 59 nTPM
cerebellum: 57 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.89
gnomAD pLI: 0
gnomAD missense Z: 0.53
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NT5DC1 as an antibody target. Whether an autoantibody or antibody against NT5DC1 could matter depends on whether native NT5DC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NT5DC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NT5DC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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