NT5C1A

Protein identityUniProt · HPA

UniProt accession

Q9BXI3

Gene

NT5C1A

Ensembl

ENSG00000116981

Chromosome

1

Canonical length

368 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

Cytosolic nucleotidases, such as NT5C1A, dephosphorylate nucleoside monophosphates (Hunsucker et al., 2001 [PubMed 11133996]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

368 residues, UniProt reviewed canonical sequence.

>Q9BXI3|NT5C1A
     1  MEPGQPREPQ EPREPGPGAE TAAAPVWEEA KIFYDNLAPK KKPKSPKPQN AVTIAVSSRA
    61  LFRMDEEQQI YTEQGVEEYV RYQLEHENEP FSPGPAFPFV KALEAVNRRL RELYPDSEDV
   121  FDIVLMTNNH AQVGVRLINS INHYDLFIER FCMTGGNSPI CYLKAYHTNL YLSADAEKVR
   181  EAIDEGIAAA TIFSPSRDVV VSQSQLRVAF DGDAVLFSDE SERIVKAHGL DRFFEHEKAH
   241  ENKPLAQGPL KGFLEALGRL QKKFYSKGLR LECPIRTYLV TARSAASSGA RALKTLRSWG
   301  LETDEALFLA GAPKGPLLEK IRPHIFFDDQ MFHVAGAQEM GTVAAHVPYG VAQTPRRTAP
   361  AKQAPSAQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NT5C1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.3

Highest tissue expression

73 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NT5C1A.

Disease | AutoantibodyPubMed

Conditions in which antibodies against NT5C1A are reported. Each links to that disease's full target list.

• Myositis 13
• Dermatomyositis 5
• Sjogren's Syndrome 5
• Polymyositis 4
• Lupus Erythematosus, Systemic 3

Showing 5 of 7 — disease pages carrying at least 10 antigens.

ReferencesPubMed · IEDB

Publications for NT5C1A from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.96

gnomAD pLI

0

gnomAD missense Z

0.87

DepMap mean gene effect

0.01

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• adenosine metabolic process
• allantoin metabolic process
• AMP catabolic process
• dAMP catabolic process
• dGMP catabolic process
• IMP catabolic process
• nucleoside metabolic process

Molecular functions

• 5'-deoxynucleotidase activity
• 5'-nucleotidase activity
• magnesium ion binding
• nucleotide binding

Cellular components

• cytoplasm
• cytosol

Protein domainsUniProt · Pfam · InterPro

• 5-nucleotidase
• 5'-nucleotidase

KeywordsUniProt

• Cytoplasm
• Hydrolase
• Magnesium
• Nucleotide metabolism
• Nucleotide-binding