NSG2
Neuronal vesicle trafficking-associated protein 2
Also known as: CALY3, HMP19, NSG2_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9Y328
- Gene
- NSG2
- Ensembl
- ENSG00000170091
- Chromosome
- 5
- Canonical length
- 171 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins
- Subcellular location
- Golgi apparatus
OverviewNCBI Gene
Predicted to enable clathrin light chain binding activity. Predicted to be involved in clathrin coat assembly and endosomal transport. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
171 residues, UniProt reviewed canonical sequence.
>Q9Y328|NSG2
1 MVKLNSNPSE KGTKPPSVED GFQTVPLITP LEVNHLQLPA PEKVIVKTRT EYQPEQKNKG
61 KFRVPKIAEF TVTILVSLAL AFLACIVFLV VYKAFTYDHS CPEGFVYKHK RCIPASLDAY
121 YSSQDPNSRS RFYTVISHYS VAKQSTARAI GPWLSAAAVI HEPKPPKTQG HLocalizationUniProt · AlphaFold · HPA
Whether an antibody against NSG2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.63
- Highest tissue expression
- 443 nTPM
Expression across tissuesHPA
Tissue
- basal ganglia: 443 nTPM
- hypothalamus: 244 nTPM
- cerebral cortex: 187 nTPM
- amygdala: 186 nTPM
- hippocampal formation: 159 nTPM
- cerebellum: 118 nTPM
Single-cell type
- brain inhibitory neurons: 265 nCPM
- retinal amacrine cells: 254 nCPM
- oligodendrocyte progenitor cells: 176 nCPM
- other brain neurons: 176 nCPM
- brain excitatory neurons: 115 nCPM
- adrenal medulla cells: 96 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- basal ganglia: 436 nTPM
- hypothalamus: 390 nTPM
- cerebral cortex: 337 nTPM
- hippocampal formation: 260 nTPM
- amygdala: 249 nTPM
- pons: 239 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.43
- gnomAD pLI
- 0.88
- gnomAD missense Z
- 0.66
- DepMap mean gene effect
- 0.19
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 0% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- clathrin coat assembly
- endosomal transport
- regulation of postsynaptic membrane neurotransmitter receptor levels
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads NSG2 as an antibody target. Whether an autoantibody or antibody against NSG2 could matter depends on whether native NSG2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
NSG2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label NSG2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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