Seroatlas · Human Serome Atlas

NSFL1C

NSFL1 cofactor p47

Also known as: dJ776F14.1, NSF1C_HUMAN, p47, UBX1, UBXD10, UBXN2C

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UNZ2
Gene
NSFL1C
Ensembl
ENSG00000088833
Chromosome
20
Canonical length
370 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Plasma membrane,Cytosol
Quaternary structure
Homohexamer

OverviewNCBI Gene

N-ethylmaleimide-sensitive factor (NSF) and valosin-containing protein (p97) are two ATPases known to be involved in transport vesicle/target membrane fusion and fusions between membrane compartments. A trimer of the protein encoded by this gene binds a hexamer of cytosolic p97 and is required for p97-mediated regrowth of Golgi cisternae from mitotic Golgi fragments. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, May 2011]

Canonical amino-acid sequenceUniProt

370 residues, UniProt reviewed canonical sequence.

>Q9UNZ2|NSFL1C
     1  MAAERQEALR EFVAVTGAEE DRARFFLESA GWDLQIALAS FYEDGGDEDI VTISQATPSS
    61  VSRGTAPSDN RVTSFRDLIH DQDEDEEEEE GQRFYAGGSE RSGQQIVGPP RKKSPNELVD
   121  DLFKGAKEHG AVAVERVTKS PGETSKPRPF AGGGYRLGAA PEEESAYVAG EKRQHSSQDV
   181  HVVLKLWKSG FSLDNGELRS YQDPSNAQFL ESIRRGEVPA ELRRLAHGGQ VNLDMEDHRD
   241  EDFVKPKGAF KAFTGEGQKL GSTAPQVLST SSPAQQAENE AKASSSILID ESEPTTNIQI
   301  RLADGGRLVQ KFNHSHRISD IRLFIVDARP AMAATSFILM TTFPNKELAD ESQTLKEANL
   361  LNAVIVQRLT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NSFL1C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
69 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 69 nTPM
  • choroid plexus: 68 nTPM
  • adrenal gland: 42 nTPM
  • tongue: 41 nTPM
  • skin: 40 nTPM
  • cerebral cortex: 37 nTPM

Single-cell type

  • oocytes: 272 nCPM
  • esophageal apical cells: 234 nCPM
  • syncytiotrophoblasts: 204 nCPM
  • extravillous trophoblasts: 200 nCPM
  • cytotrophoblasts: 187 nCPM
  • esophageal suprabasal cells: 186 nCPM

Immune cell

  • eosinophil: 81 nTPM
  • neutrophil: 69 nTPM
  • naive B-cell: 36 nTPM
  • memory B-cell: 35 nTPM
  • basophil: 31 nTPM
  • myeloid DC: 30 nTPM

Brain region

  • choroid plexus: 37 nTPM
  • cerebral cortex: 35 nTPM
  • pons: 34 nTPM
  • white matter: 32 nTPM
  • basal ganglia: 32 nTPM
  • midbrain: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.59
gnomAD pLI
0.05
gnomAD missense Z
1.46
DepMap mean gene effect
-0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NSFL1C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NSFL1C as an antibody target. Whether an autoantibody or antibody against NSFL1C could matter depends on whether native NSFL1C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NSFL1C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NSFL1C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NSFL1C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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