Seroatlas · Human Serome Atlas

NRTN

Neurturin

Also known as: NRTN_HUMAN, NTN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99748
Gene: NRTN
Ensembl: ENSG00000171119
Chromosome: 19
Canonical length: 197 aa
Protein class: Disease related genes, Predicted secreted proteins
Subcellular location: Golgi apparatus
Secretome location: Secreted to blood
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein signals through the RET receptor tyrosine kinase and a GPI-linked coreceptor, and promotes survival of neuronal populations. A neurturin mutation has been described in a family with Hirschsprung Disease. [provided by RefSeq, Aug 2016]

Canonical amino-acid sequenceUniProt

197 residues, UniProt reviewed canonical sequence.

>Q99748|NRTN
     1  MQRWKAAALA SVLCSSVLSI WMCREGLLLS HRLGPALVPL HRLPRTLDAR IARLAQYRAL
    61  LQGAPDAMEL RELTPWAGRP PGPRRRAGPR RRRARARLGA RPCGLRELEV RVSELGLGYA
   121  SDETVLFRYC AGACEAAARV YDLGLRRLRQ RRRLRRERVR AQPCCRPTAY EDEVSFLDAH
   181  SRYHTVHELS ARECACV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NRTN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 19 nTPM
pancreas: 13 nTPM
liver: 11 nTPM
colon: 7.1 nTPM
stomach: 7 nTPM
retina: 6.3 nTPM

Single-cell type

esophageal apical cells: 137 nCPM
rod photoreceptor cells: 97 nCPM
enterocytes: 77 nCPM
paneth cells: 54 nCPM
salivary acinar cells: 45 nCPM
cone photoreceptor cells: 37 nCPM

Immune cell

plasmacytoid DC: 0.2 nTPM
T-reg: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

midbrain: 1.3 nTPM
pons: 1.2 nTPM
medulla oblongata: 1.1 nTPM
cerebellum: 1 nTPM
white matter: 1 nTPM
cerebral cortex: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.29
gnomAD pLI: 0.03
gnomAD missense Z: 0.68
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NRTN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

GFRA2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NRTN as an antibody target. Whether an autoantibody or antibody against NRTN could matter depends on whether native NRTN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NRTN is annotated as secreted, so native NRTN circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label NRTN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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