Seroatlas · Human Serome Atlas

NRSN2

Neurensin-2

Also known as: C20orf98, dJ1103G7.6, NRSN2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9GZP1
Gene: NRSN2
Ensembl: ENSG00000125841
Chromosome: 20
Canonical length: 204 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm,Vesicles,Cytosol

OverviewNCBI Gene

Predicted to be involved in nervous system development. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

204 residues, UniProt reviewed canonical sequence.

>Q9GZP1|NRSN2
     1  MMPSCNRSCS CSRGPSVEDG KWYGVRSYLH LFYEDCAGTA LSDDPEGPPV LCPRRPWPSL
    61  CWKISLSSGT LLLLLGVAAL TTGYAVPPKL EGIGEGEFLV LDQRAADYNQ ALGTCRLAGT
   121  ALCVAAGVLL AICLFWAMIG WLSQDTKAEP LDPEADSHVE VFGDEPEQQL SPIFRNASGQ
   181  SWFSPPASPF GQSSVQTIQP KRDS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NRSN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 153 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 153 nTPM
amygdala: 121 nTPM
hippocampal formation: 114 nTPM
basal ganglia: 112 nTPM
hypothalamus: 89 nTPM
cerebellum: 79 nTPM

Single-cell type

brain inhibitory neurons: 44 nCPM
early primary spermatocytes: 42 nCPM
retinal bipolar cells: 36 nCPM
other brain neurons: 36 nCPM
brain excitatory neurons: 36 nCPM
rod photoreceptor cells: 32 nCPM

Immune cell

naive B-cell: 7 nTPM
memory B-cell: 5.6 nTPM
plasmacytoid DC: 3.5 nTPM
NK-cell: 2.8 nTPM
memory CD8 T-cell: 2.6 nTPM
gdT-cell: 2.4 nTPM

Brain region

cerebral cortex: 143 nTPM
basal ganglia: 130 nTPM
amygdala: 116 nTPM
hippocampal formation: 113 nTPM
white matter: 111 nTPM
hypothalamus: 110 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.57
gnomAD pLI: 0
gnomAD missense Z: 0.37
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

nervous system development

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NRSN2 as an antibody target. Whether an autoantibody or antibody against NRSN2 could matter depends on whether native NRSN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NRSN2 is annotated at the cell surface, where native NRSN2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NRSN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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