Seroatlas · Human Serome Atlas

NRSN1

Neurensin-1

Also known as: NRSN1_HUMAN, p24, VMP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IZ57
Gene: NRSN1
Ensembl: ENSG00000152954
Chromosome: 6
Canonical length: 195 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to be involved in nervous system development. Predicted to be located in cytoplasmic vesicle and growth cone. Predicted to be active in neuron projection; neuronal cell body; and transport vesicle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

195 residues, UniProt reviewed canonical sequence.

>Q8IZ57|NRSN1
     1  MSSCSNVCGS RQAQAAAEGG YQRYGVRSYL HQFYEDCTAS IWEYEDDFQI QRSPNRWSSV
    61  FWKVGLISGT VFVILGLTVL AVGFLVPPKI EAFGEADFVV VDTHAVQFNS ALDMYKLAGA
   121  VLFCIGGTSM AGCLLMSVFV KSYSKEEKFL QQKFKERIAD IKAHTQPVTK APGPGETKIP
   181  VTLSRVQNVQ PLLAT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NRSN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 75 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 75 nTPM
basal ganglia: 57 nTPM
hypothalamus: 53 nTPM
amygdala: 39 nTPM
midbrain: 24 nTPM
hippocampal formation: 22 nTPM

Single-cell type

thyrotrophs: 270 nCPM
retinal horizontal cells: 254 nCPM
lactotrophs: 164 nCPM
brain inhibitory neurons: 150 nCPM
gonadotrophs: 141 nCPM
other brain neurons: 133 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 205 nTPM
pons: 189 nTPM
basal ganglia: 185 nTPM
cerebral cortex: 180 nTPM
hypothalamus: 176 nTPM
thalamus: 165 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.5
gnomAD pLI: 0
gnomAD missense Z: 0.59
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

nervous system development

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NRSN1 as an antibody target. Whether an autoantibody or antibody against NRSN1 could matter depends on whether native NRSN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NRSN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NRSN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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