NRN1L
Neuritin-like protein
Also known as: MRCC2446, NRN1L_HUMAN, UNQ2446
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q496H8
- Gene
- NRN1L
- Ensembl
- ENSG00000188038
- Chromosome
- 16
- Canonical length
- 165 aa
- Protein class
- Predicted intracellular proteins, Predicted secreted proteins
- Secretome location
- Secreted - unknown location
OverviewNCBI Gene
The protein encoded by this gene is extracellular and enhances both neurite growth and neuronal survival. The encoded protein is found both as a GPI anchored membrane-bound form and as a secreted form. This activity-related ligand functions as a homodimer or heterodimer. [provided by RefSeq, Feb 2017]
Canonical amino-acid sequenceUniProt
165 residues, UniProt reviewed canonical sequence.
>Q496H8|NRN1L
1 MMRCCRRRCC CRQPPHALRP LLLLPLVLLP PLAAAAAGPN RCDTIYQGFA ECLIRLGDSM
61 GRGGELETIC RSWNDFHACA SQVLSGCPEE AAAVWESLQQ EARQAPRPNN LHTLCGAPVH
121 VRERGTGSET NQETLRATAP ALPMAPAPPL LAAALALAYL LRPLALocalizationUniProt · AlphaFold · HPA
Whether an antibody against NRN1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.52
- Highest tissue expression
- 25 nTPM
Expression across tissuesHPA
Tissue
- choroid plexus: 25 nTPM
- basal ganglia: 10 nTPM
- cerebellum: 9.1 nTPM
- pituitary gland: 6.9 nTPM
- hypothalamus: 6.5 nTPM
- retina: 5.1 nTPM
Single-cell type
- retinal pigment epithelial cells: 4.3 nCPM
- astrocytes: 3.4 nCPM
- bergmann glia: 3 nCPM
- other brain neurons: 2.3 nCPM
- retinal bipolar cells: 2.3 nCPM
- brain inhibitory neurons: 2 nCPM
Immune cell
- gdT-cell: 1 nTPM
- MAIT T-cell: 0.6 nTPM
- memory CD4 T-cell: 0.6 nTPM
- neutrophil: 0.6 nTPM
- classical monocyte: 0.5 nTPM
- memory B-cell: 0.5 nTPM
Brain region
- choroid plexus: 15 nTPM
- cerebellum: 10 nTPM
- basal ganglia: 9.2 nTPM
- white matter: 8.8 nTPM
- hypothalamus: 8 nTPM
- cerebral cortex: 7.7 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.78
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.31
- DepMap mean gene effect
- -0.01
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads NRN1L as an antibody target. Whether an autoantibody or antibody against NRN1L could matter depends on whether native NRN1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
NRN1L is annotated at the cell surface, where native NRN1L is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label NRN1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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