Seroatlas · Human Serome Atlas

NRN1

Neuritin

Also known as: NRN, NRN1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NPD7
Gene: NRN1
Ensembl: ENSG00000124785
Chromosome: 6
Canonical length: 142 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of the neuritin family, and is expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal structures associated with plasticity in the adult. The expression of this gene can be induced by neural activity and neurotrophins. The encoded protein contains a consensus cleavage signal found in glycosylphoshatidylinositol (GPI)-anchored proteins. The encoded protein promotes neurite outgrowth and arborization, suggesting its role in promoting neuritogenesis. Overexpression of the encoded protein may be associated with astrocytoma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

142 residues, UniProt reviewed canonical sequence.

>Q9NPD7|NRN1
     1  MGLKLNGRYI SLILAVQIAY LVQAVRAAGK CDAVFKGFSD CLLKLGDSMA NYPQGLDDKT
    61  NIKTVCTYWE DFHSCTVTAL TDCQEGAKDM WDKLRKESKN LNIQGSLFEL CGSGNGAAGS
   121  LLPAFPVLLV SLSAALATWL SF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NRN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 187 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 187 nTPM
cerebellum: 163 nTPM
hippocampal formation: 132 nTPM
amygdala: 119 nTPM
parathyroid gland: 76 nTPM
adipose tissue: 65 nTPM

Single-cell type

schwann cells: 184 nCPM
smooth muscle cells: 141 nCPM
vascular endothelial cells: 126 nCPM
lymphatic endothelial cells: 105 nCPM
extravillous trophoblasts: 101 nCPM
brain excitatory neurons: 94 nCPM

Immune cell

MAIT T-cell: 2.6 nTPM
neutrophil: 2.3 nTPM
memory B-cell: 0.3 nTPM
memory CD8 T-cell: 0.3 nTPM
memory CD4 T-cell: 0.2 nTPM
plasmacytoid DC: 0.2 nTPM

Brain region

hippocampal formation: 193 nTPM
cerebral cortex: 154 nTPM
thalamus: 112 nTPM
amygdala: 87 nTPM
white matter: 82 nTPM
cerebellum: 81 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.46
gnomAD pLI: 0.86
gnomAD missense Z: 1.14
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

identical protein binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NRN1 as an antibody target. Whether an autoantibody or antibody against NRN1 could matter depends on whether native NRN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NRN1 is annotated at the cell surface, where native NRN1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NRN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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