Seroatlas · Human Serome Atlas

NRM

Nurim

Also known as: NRM_HUMAN, NRM29

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IXM6
Gene: NRM
Ensembl: ENSG00000137404
Chromosome: 6
Canonical length: 262 aa
Protein class: Predicted membrane proteins
Subcellular location: Nuclear membrane

OverviewNCBI Gene

The protein encoded by this gene contains transmembrane domains and resides within the inner nuclear membrane, where it is tightly associated with the nucleus. This protein shares homology with isoprenylcysteine carboxymethyltransferase enzymes. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

262 residues, UniProt reviewed canonical sequence.

>Q8IXM6|NRM
     1  MAPALLLIPA ALASFILAFG TGVEFVRFTS LRPLLGGIPE SGGPDARQGW LAALQDRSIL
    61  APLAWDLGLL LLFVGQHSLM AAERVKAWTS RYFGVLQRSL YVACTALALQ LVMRYWEPIP
   121  KGPVLWEARA EPWATWVPLL CFVLHVISWL LIFSILLVFD YAELMGLKQV YYHVLGLGEP
   181  LALKSPRALR LFSHLRHPVC VELLTVLWVV PTLGTDRLLL AFLLTLYLGL AHGLDQQDLR
   241  YLRAQLQRKL HLLSRPQDGE AE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NRM can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

endometrium: 20 nTPM
cervix: 16 nTPM
testis: 15 nTPM
blood vessel: 15 nTPM
bone marrow: 13 nTPM
vagina: 13 nTPM

Single-cell type

oligodendrocyte progenitor cells: 2.1 nCPM
microglia: 2 nCPM
monocyte progenitors: 1.7 nCPM
renal collecting duct principal cells: 1.1 nCPM
kupffer cells: 1 nCPM
loop of henle epithelial cells: 1 nCPM

Immune cell

plasmacytoid DC: 13 nTPM
classical monocyte: 13 nTPM
myeloid DC: 12 nTPM
naive B-cell: 10 nTPM
memory B-cell: 10 nTPM
neutrophil: 6.5 nTPM

Brain region

medulla oblongata: 2.1 nTPM
white matter: 1.8 nTPM
pons: 1.7 nTPM
thalamus: 1.7 nTPM
cerebral cortex: 1.2 nTPM
hypothalamus: 1.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0.02
gnomAD missense Z: 1.24
DepMap mean gene effect: -0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Nurim-like

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NRM as an antibody target. Whether an autoantibody or antibody against NRM could matter depends on whether native NRM is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NRM is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NRM as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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