Seroatlas · Human Serome Atlas

NRK

Nik-related protein kinase

Also known as: DKFZp686A17109, NRK_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z2Y5
Gene
NRK
Ensembl
ENSG00000123572
Chromosome
X
Canonical length
1582 aa
Protein class
Enzymes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

The mouse ortholog of this gene encodes a protein kinase required for JNK activation. The encoded protein may be involved in the induction of actin polymerization in late embryogenesis.[provided by RefSeq, Jun 2010]

Canonical amino-acid sequenceUniProt

1582 residues, UniProt reviewed canonical sequence.

>Q7Z2Y5|NRK
     1  MAGPGGWRDR EVTDLGHLPD PTGIFSLDKT IGLGTYGRIY LGLHEKTGAF TAVKVMNARK
    61  TPLPEIGRRV RVNKYQKSVG WRYSDEEEDL RTELNLLRKY SFHKNIVSFY GAFFKLSPPG
   121  QRHQLWMVME LCAAGSVTDV VRMTSNQSLK EDWIAYICRE ILQGLAHLHA HRVIHRDIKG
   181  QNVLLTHNAE VKLVDFGVSA QVSRTNGRRN SFIGTPYWMA PEVIDCDEDP RRSYDYRSDV
   241  WSVGITAIEM AEGAPPLCNL QPLEALFVIL RESAPTVKSS GWSRKFHNFM EKCTIKNFLF
   301  RPTSANMLQH PFVRDIKNER HVVESLTRHL TGIIKKRQKK GIPLIFEREE AIKEQYTVRR
   361  FRGPSCTHEL LRLPTSSRCR PLRVLHGEPS QPRWLPDREE PQVQALQQLQ GAARVFMPLQ
   421  ALDSAPKPLK GQAQAPQRLQ GAARVFMPLQ AQVKAKASKP LQMQIKAPPR LRRAARVLMP
   481  LQAQVRAPRL LQVQSQVSKK QQAQTQTSEP QDLDQVPEEF QGQDQVPEQQ RQGQAPEQQQ
   541  RHNQVPEQEL EQNQAPEQPE VQEQAAEPAQ AETEAEEPES LRVNAQVFLP LLSQDHHVLL
   601  PLHLDTQVLI PVEGQTEGSP QAQAWTLEPP QAIGSVQALI EGLSRDLLRA PNSNNSKPLG
   661  PLQTLMENLS SNRFYSQPEQ AREKKSKVST LRQALAKRLS PKRFRAKSSW RPEKLELSDL
   721  EARRQRRQRR WEDIFNQHEE ELRQVDKDKE DESSDNDEVF HSIQAEVQIE PLKPYISNPK
   781  KIEVQERSPS VPNNQDHAHH VKFSSSVPQR SLLEQAQKPI DIRQRSSQNR QNWLAASESS
   841  SEEESPVTGR RSQSSPPYST IDQKLLVDIH VPDGFKVGKI SPPVYLTNEW VGYNALSEIF
   901  RNDWLTPAPV IQPPEEDGDY VELYDASADT DGDDDDESND TFEDTYDHAN GNDDLDNQVD
   961  QANDVCKDHD DDNNKFVDDV NNNYYEAPSC PRASYGRDGS CKQDGYDGSR GKEEAYRGYG
  1021  SHTANRSHGG SAASEDNAAI GDQEEHAANI GSERRGSEGD GGKGVVRTSE ESGALGLNGE
  1081  ENCSETDGPG LKRPASQDFE YLQEEPGGGN EASNAIDSGA APSAPDHESD NKDISESSTQ
  1141  SDFSANHSSP SKGSGMSADA NFASAILYAG FVEVPEESPK QPSEVNVNPL YVSPACKKPL
  1201  IHMYEKEFTS EICCGSLWGV NLLLGTRSNL YLMDRSGKAD ITKLIRRRPF RQIQVLEPLN
  1261  LLITISGHKN RLRVYHLTWL RNKILNNDPE SKRRQEEMLK TEEACKAIDK LTGCEHFSVL
  1321  QHEETTYIAI ALKSSIHLYA WAPKSFDEST AIKVCIDQSA DSEGDYMSYQ AYIRILAKIQ
  1381  AADPVNRFKR PDELLHLLKL KVFPTLDHKP VTVDLAIGSE KRLKIFFSSA DGYHLIDAES
  1441  EVMSDVTLPK NPLEIIIPQN IIILPDCLGI GMMLTFNAEA LSVEANEQLF KKILEMWKDI
  1501  PSSIAFECTQ RTTGWGQKAI EVRSLQSRVL ESELKRRSIK KLRFLCTRGD KLFFTSTLRN
  1561  HHSRVYFMTL GKLEELQSNY DV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NRK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
24 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 24 nTPM
  • placenta: 23 nTPM
  • adrenal gland: 15 nTPM
  • gallbladder: 9.4 nTPM
  • kidney: 5.8 nTPM
  • prostate: 4.6 nTPM

Single-cell type

  • leydig cells: 608 nCPM
  • cytotrophoblasts: 295 nCPM
  • syncytiotrophoblasts: 177 nCPM
  • gonadotrophs: 151 nCPM
  • distal convoluted tubule cells: 145 nCPM
  • adrenal cortex cells: 135 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 15 nTPM
  • pons: 1.3 nTPM
  • white matter: 0.9 nTPM
  • midbrain: 0.8 nTPM
  • cerebral cortex: 0.7 nTPM
  • medulla oblongata: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.29
gnomAD pLI
0.99
gnomAD missense Z
0.66
DepMap mean gene effect
0.2
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NRK as an antibody target. Whether an autoantibody or antibody against NRK could matter depends on whether native NRK is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NRK is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NRK as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NRK. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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